Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

被引：247

作者：

Milazzo, Giorgio ^{[1
]}

Mercatelli, Daniele ^{[1
]}

Di Muzio, Giulia ^{[1
]}

Triboli, Luca ^{[1
]}

De Rosa, Piergiuseppe ^{[1
]}

Perini, Giovanni ^{[1
]}

Giorgi, Federico M. ^{[1
]}

机构：

[1] Univ Bologna, Dept Pharm & Biotechnol, Via Selmi 3, I-41026 Bologna, Italy

来源：

GENES | 2020年 / 11卷 / 05期

关键词：

histone deacetylases; HDAC; chromatin; epigenetics; epigenomics; HDAC inhibitors; HDACi; gene networks; cancer; phylogenesis; INHIBITOR VALPROIC ACID; CANCER STEM-CELLS; CLASS-I HDACS; 2 CATALYTIC DOMAINS; LUNG-CANCER; PHASE-I; HEPATOCELLULAR-CARCINOMA; SELECTIVE-INHIBITION; PANCREATIC-CANCER; BREAST-CANCER;

D O I：

10.3390/genes11050556

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Histone deacetylases (HDACs) are evolutionary conserved enzymes which operate by removing acetyl groups from histones and other protein regulatory factors, with functional consequences on chromatin remodeling and gene expression profiles. We provide here a review on the recent knowledge accrued on the zinc-dependent HDAC protein family across different species, tissues, and human pathologies, specifically focusing on the role of HDAC inhibitors as anti-cancer agents. We will investigate the chemical specificity of different HDACs and discuss their role in the human interactome as members of chromatin-binding and regulatory complexes.

引用

页数：49

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