Lipophilic Pt(II) complexes with selective efficacy against cisplatin-resistant testicular cancer cells

被引：9

作者：

Biersack, Bernhard ^{[1
]}

Dietrich, Andrea ^{[2
]}

Zoldakova, Miroslava ^{[1
]}

Kalinowski, Bernd ^{[3
]}

Paschke, Reinhard ^{[3
]}

Schobert, Rainer ^{[1
]}

Mueller, Thomas ^{[2
]}

机构：

[1] Univ Bayreuth, Organ Chem Lab, D-95440 Bayreuth, Germany

[2] Univ Halle Wittenberg, Dept Internal Med 4, D-06120 Halle, Germany

[3] Univ Halle Wittenberg, Bioctr, D-06120 Halle, Germany

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2011年 / 105卷 / 12期

关键词：

Platinum complexes; Terpenes; Cisplatin resistance; Testicular cancer; BIOLOGICAL EVALUATION; PLATINUM; BINDING;

D O I：

10.1016/j.jinorgbio.2011.08.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of dichloridoplatinum(II) complexes with selective and high cytotoxicity [IC90(96 h) <= 3 mu M] against cisplatin-resistant 1411 HP testicular cancer cells were identified. They bear stationary 6-aminomethylnicotinate or 2,4-diaminobutyrate ligands esterified with lipophilic terpenyl residues, i.e., (-)/(+)-menthyl, (+)-cedrenyl, (-)-menthoxypropyl, or with a decyl-tethered 1,1,2-triphenylethene. They accumulated to a larger extent in 1411 HP cells than in cells of the cisplatin-sensitive H12.1 germ cell tumour. Their mechanism of apoptosis induction differed from that of cisplatin by being independent of p53 and of caspase-3 activation and by an early loss of the mitochondrial membrane potential. The new complexes are promising candidates for the treatment of cisplatin-resistant testicular tumours. (C) 2011 Elsevier Inc. All rights reserved.

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页码：1630 / 1637

页数：8

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