Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis

被引：3

作者：

Jang, Woong Sik ^{[1
]}

Kim, Sukyung ^{[2
]}

Podder, Biswajit ^{[2
]}

Jyoti, Md Anirban ^{[2
]}

Nam, Kung-Woo ^{[3
]}

Lee, Byung-Eui ^{[4
]}

Song, Ho-Yeon ^{[1
,2
]}

机构：

[1] Soonchunhyang Univ, Reg Innovat Ctr, Asan 336745, South Korea

[2] Soonchunhyang Univ, Sch Med, Dept Microbiol & Immunol, Cheonan 330090, South Korea

[3] Soonchunhyang Univ, Dept Life Sci & Biotechnol, Asan 336745, South Korea

[4] Soonchunhyang Univ, Dept Chem, Asan 336745, South Korea

来源：

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY | 2015年 / 25卷 / 06期

关键词：

Mycobacterium tuberculosis; tamoxifen; intracellular killing; MDR; XDR; MEDICINAL-PLANTS; IN-VIVO; ANTIBACTERIAL; EXTRACTS;

D O I：

10.4014/jmb.1412.12023

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Recently, it has become a struggle to treat tuberculosis with the current commercial anti-tuberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the anti-mycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drug-sensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had anti-tuberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 mu g/ml) as well as drug-resistant strains (MIC, 6.25 to 12.5 mu g/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.

引用

页码：946 / 950

页数：5

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