Ribonuclease P

被引：29

作者：

Altman, Sidney ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2011年 / 366卷 / 1580期

关键词：

RNA enzyme; substrate; evolution; NUCLEAR RNASE-P; ESCHERICHIA-COLI; PRECURSOR MOLECULE; EXPRESSION; SUBUNIT; PROTEIN; ENZYME; SEQUENCE; OPERON; GENES;

D O I：

10.1098/rstb.2011.0142

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene coding for the RNA subunit of ribonuclease P (RNase P) is essential in all free-living organisms. The RNA subunit, itself, is an enzyme and, from its evolutionary tree, we can infer that it is a very ancient molecule. The specificity of this enzyme is that it cleaves other RNA molecules at the junction of single-stranded and the 50 end of double-stranded regions of RNA. One can speculate that this molecule was very useful in an ancient world in cleaving long pieces of RNA, which must have contained hairpin regions in it, into shorter molecules with the capability of different functions from the longer parent. Today, the specificity of the enzyme can be used in designing drug therapies.

引用

页码：2936 / 2941

页数：6

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