Association between type 1 diabetes and GWAS SNPs in the southeast US Caucasian population

被引：79
作者：
Reddy, M. V. Prasad Linga [1 ,2 ]
Wang, H. [1 ,2 ]
Liu, S. [1 ,2 ]
Bode, B. [3 ]
Reed, J. C. [4 ]
Steed, R. D. [4 ]
Anderson, S. W. [5 ]
Steed, L. [1 ,2 ]
Hopkins, D. [1 ,2 ]
She, J-X [1 ,2 ]
机构：
[1] Med Coll Georgia, Ctr Biotechnol & Genom Med, Augusta, GA 30912 USA
[2] Med Coll Georgia, Dept Pathol, Augusta, GA 30912 USA
[3] Atlanta Diabet Associates, Atlanta, GA USA
[4] SE Endocrine & Diabet, Atlanta, GA USA
[5] Pediat Endocrine Associates, Atlanta, GA USA
来源：
GENES AND IMMUNITY | 2011年 / 12卷 / 03期
关键词：
genetics; T1D; candidate genes; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY; LOCI; METAANALYSIS; RISK; CTLA4;
D O I：
10.1038/gene.2010.70
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The present study was conducted to assess genetic associations for type 1 diabetes (T1D) reported in previous genome-wide association studies (GWAS). A total of 21 previously reported single-nucleotide polymorphisms (SNPs) were genotyped by TaqMan assays in 1434 Caucasian T1D patients and 1864 normal controls from Georgia. Analysis of the samples identified 18 SNPs (PTPN22, INS, IFIH1, SH2B3, ERBB3, CTLA4, C14orf181, CTSH, CLEC16A, CD69, ITPR3, C6orf173, SKAP2, PRKCQ, RNLS, IL27, SIRPG and CTRB2) with putative association. Genes and Immunity (2011) 12, 208-212; doi:10.1038/gene.2010.70; published online 27 January 2011
引用
收藏
页码：208 / 212
页数：5
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共 25 条
  • [1] Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis
    Aulchenko, Yurii S.
    Hoppenbrouwers, Ilse A.
    Ramagopalan, Sreeram V.
    Broer, Linda
    Jafari, Naghmeh
    Hillert, Jan
    Link, Jenny
    Lundstrom, Wangko
    Greiner, Eva
    Sadovnick, A. Dessa
    Goossens, Dirk
    Van Broeckhoven, Christine
    Del-Favero, Jurgen
    Ebers, George C.
    Oostra, Ben A.
    van Duijn, Cornelia M.
    Hintzen, Rogier Q.
    [J]. NATURE GENETICS, 2008, 40 (12) : 1402 - 1403
  • [2] Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    Barrett, Jeffrey C.
    Clayton, David G.
    Concannon, Patrick
    Akolkar, Beena
    Cooper, Jason D.
    Erlich, Henry A.
    Julier, Cecile
    Morahan, Grant
    Nerup, Jorn
    Nierras, Concepcion
    Plagnol, Vincent
    Pociot, Flemming
    Schuilenburg, Helen
    Smyth, Deborah J.
    Stevens, Helen
    Todd, John A.
    Walker, Neil M.
    Rich, Stephen S.
    [J]. NATURE GENETICS, 2009, 41 (06) : 703 - 707
  • [3] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    Burton, Paul R.
    Clayton, David G.
    Cardon, Lon R.
    Craddock, Nick
    Deloukas, Panos
    Duncanson, Audrey
    Kwiatkowski, Dominic P.
    McCarthy, Mark I.
    Ouwehand, Willem H.
    Samani, Nilesh J.
    Todd, John A.
    Donnelly, Peter
    Barrett, Jeffrey C.
    Davison, Dan
    Easton, Doug
    Evans, David
    Leung, Hin-Tak
    Marchini, Jonathan L.
    Morris, Andrew P.
    Spencer, Chris C. A.
    Tobin, Martin D.
    Attwood, Antony P.
    Boorman, James P.
    Cant, Barbara
    Everson, Ursula
    Hussey, Judith M.
    Jolley, Jennifer D.
    Knight, Alexandra S.
    Koch, Kerstin
    Meech, Elizabeth
    Nutland, Sarah
    Prowse, Christopher V.
    Stevens, Helen E.
    Taylor, Niall C.
    Walters, Graham R.
    Walker, Neil M.
    Watkins, Nicholas A.
    Winzer, Thilo
    Jones, Richard W.
    McArdle, Wendy L.
    Ring, Susan M.
    Strachan, David P.
    Pembrey, Marcus
    Breen, Gerome
    St Clair, David
    Caesar, Sian
    Gordon-Smith, Katherine
    Jones, Lisa
    Fraser, Christine
    Green, Elain K.
    [J]. NATURE, 2007, 447 (7145) : 661 - 678
  • [4] Identification of a Novel Risk Locus for Multiple Sclerosis at 13q31.3 by a Pooled Genome-Wide Scan of 500,000 Single Nucleotide Polymorphisms
    Comabella, Manuel
    Craig, David W.
    Camina-Tato, Montse
    Morcillo, Carlos
    Lopez, Cristina
    Navarro, Arcadi
    Rio, Jordi
    Montalban, Xavier
    Martin, Roland
    [J]. PLOS ONE, 2008, 3 (10):
  • [5] Genome-Wide Scan for Linkage to Type 1 Diabetes in 2,496 Multiplex Families From the Type 1 Diabetes Genetics Consortium
    Concannon, Patrick
    Chen, Wei-Min
    Julier, Cecile
    Morahan, Grant
    Akolkar, Beena
    Erlich, Henry A.
    Hilner, Joan E.
    Nerup, Jorn
    Nierras, Concepcion
    Pociot, Flemming
    Todd, John A.
    Rich, Stephen S.
    [J]. DIABETES, 2009, 58 (04) : 1018 - 1022
  • [6] Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci
    Cooper, Jason D.
    Smyth, Deborah J.
    Smiles, Adam M.
    Plagnol, Vincent
    Walker, Neil M.
    Allen, James E.
    Downes, Kate
    Barrett, Jeffrey C.
    Healy, Barry C.
    Mychaleckyj, Josyf C.
    Warram, James H.
    Todd, John A.
    [J]. NATURE GENETICS, 2008, 40 (12) : 1399 - 1401
  • [7] Rapid genotyping of single nucleotide polymorphisms using novel minor groove binding DNA oligonucleotides (MGB probes)
    de Kok, JB
    Wiegerinck, ETG
    Giesendorf, BAJ
    Swinkels, DW
    [J]. HUMAN MUTATION, 2002, 19 (05) : 554 - 559
  • [8] Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
    Franke, Andre
    Hampe, Jochen
    Rosenstiel, Philip
    Becker, Christian
    Wagner, Florian
    Haesler, Robert
    Little, Randall D.
    Huse, Klaus
    Ruether, Andreas
    Balschun, Tobias
    Wittig, Michael
    ElSharawy, Abdou
    Mayr, Gabriele
    Albrecht, Mario
    Prescott, Natalie J.
    Onnie, Clive M.
    Fournier, Helene
    Keith, Tim
    Radelof, Uwe
    Platzer, Matthias
    Mathew, Christopher G.
    Stoll, Monika
    Krawczak, Michael
    Nuernberg, Peter
    Schreiber, Stefan
    [J]. PLOS ONE, 2007, 2 (08):
  • [9] Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    Fung, E. Y. M. G.
    Smyth, D. J.
    Howson, J. M. M.
    Cooper, J. D.
    Walker, N. M.
    Stevens, H.
    Wicker, L. S.
    Todd, J. A.
    [J]. GENES AND IMMUNITY, 2009, 10 (02) : 188 - 191
  • [10] Genome-wide association studies in type 1 diabetes
    Grant, Struan F. A.
    Hakonarson, Hakon
    [J]. CURRENT DIABETES REPORTS, 2009, 9 (02) : 157 - 163
123