Therapeutic Potential of Quercetin as an Antiatherosclerotic Agent in Atherosclerotic Cardiovascular Disease: A Review

被引：69
作者：
Deng, Qian [1 ]
Li, Xiao Xue [1 ]
Fang, Yanting [1 ]
Chen, Xin [1 ]
Xue, Jingui [1 ]
机构：
[1] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai, Peoples R China
来源：
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2020年 / 2020卷
基金：
中国国家自然科学基金;
关键词：
LOW-DENSITY-LIPOPROTEIN; NF-KAPPA-B; ADHESION MOLECULE EXPRESSION; CHOLESTEROL EFFLUX; INFLAMMATORY RESPONSE; ANTIOXIDANT STATUS; ENDOTHELIAL-CELLS; SIGNALING PATHWAY; ABCA1; EXPRESSION; OXIDATIVE DAMAGE;
D O I：
10.1155/2020/5926381
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest morbidity and mortality globally. It causes a huge burden on families and caregivers and high costs for medicine and surgical interventions. Given expensive surgeries and failures of most conventional treatments, medical community tries to find a more cost-effective cure. Thus, attentions have been primarily focused on food or herbs. Quercetin (Qu) extracted from food, a flavonoid component, develops potentials of alternative or complementary medicine in atherosclerosis. Due to the wide range of health benefits, researchers have considered to apply Qu as a natural compound in therapy. This review is aimed to identify the antiatherosclerosis functions of Qu in treating ASCVD such as anti-inflammatory, antioxidant properties, effects on endothelium-dependent vasodilation, and blood lipid-lowering.
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页数：12
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共 134 条
[1]  
Anand David Alexander Victor, 2016, Pharmacogn Rev, V10, P84, DOI 10.4103/0973-7847.194044
[2]   MST1 is a key regulator of beta cell apoptosis and dysfunction in diabetes [J].
Ardestani, Amin ;
Paroni, Federico ;
Azizi, Zahra ;
Kaur, Supreet ;
Khobragade, Vrushali ;
Yuan, Ting ;
Frogne, Thomas ;
Tao, Wufan ;
Oberholzer, Jose ;
Pattou, Francois ;
Conte, Julie Kerr ;
Maedler, Kathrin .
NATURE MEDICINE, 2014, 20 (04) :385-+
[3]   Autophagy as a molecular target of quercetin underlying its protective effects in human diseases [J].
Ashrafizadeh, Milad ;
Ahmadi, Zahra ;
Farkhondeh, Tahereh ;
Samarghandia, Saeed .
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, 2022, 128 (01) :200-208
[4]   Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet [J].
Atrahimovich, Dana ;
Samson, Abraham O. ;
Khattib, Ali ;
Vaya, Jacob ;
Khatib, Soliman .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
[5]   Effects of oxidized fibrinogen on the functions of blood cells, blood clotting, and rheology [J].
Azizova, O. A. ;
Aseichev, A. V. ;
Piryazev, A. P. ;
Roitman, E. V. ;
Shcheglovitova, O. N. .
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 144 (03) :397-407
[6]   Danshensu attenuates scopolamine and amyloid-β-induced cognitive impairments through the activation of PKA-CREB signaling in mice [J].
Bae, Ho Jung ;
Sowndhararajan, Kandhasamy ;
Park, Hyeon-Bae ;
Kim, So-Yeon ;
Kim, Songmun ;
Kim, Dong Hyun ;
Choi, Ji Woong ;
Jang, Dae Sik ;
Ryu, Jong Hoon ;
Park, Se Jin .
NEUROCHEMISTRY INTERNATIONAL, 2019, 131
[7]   County-level heat vulnerability of urban and rural residents in Tibet, China [J].
Bai, Li ;
Woodward, Alistair ;
Cirendunzhu ;
Liu, Qiyong .
ENVIRONMENTAL HEALTH, 2016, 15
[8]   Association between the gut microbiome and atherosclerosis [J].
Barrington, William T. ;
Lusis, Aldons J. .
NATURE REVIEWS CARDIOLOGY, 2017, 14 (12) :699-+
[9]   Pathophysiology and treatment of atherosclerosis Current view and future perspective on lipoprotein modification treatment [J].
Bergheanu, S. C. ;
Bodde, M. C. ;
Jukema, J. W. .
NETHERLANDS HEART JOURNAL, 2017, 25 (04) :231-242
[10]   Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-κB signaling pathway [J].
Bhaskar, Shobha ;
Sudhakaran, P. R. ;
Helen, A. .
CELLULAR IMMUNOLOGY, 2016, 310 :131-140
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