Nickel-Catalyzed Chemo-, Regio- and Diastereoselective Bond Formation through Proximal C-C Cleavage of Benzocyclobutenones

被引：94

作者：

Julia-Hernandez, Francisco ^{[1
]}

Ziadi, Asraa ^{[1
]}

Nishimura, Akira ^{[1
]}

Martin, Ruben ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 33期

基金：

欧洲研究理事会;

关键词：

benzocyclobutenones; C-C activation; nickel catalysis; ring strain; BETA-CARBON ELIMINATION; SITE-SELECTIVITY; RING EXPANSION; RHODIUM; CYCLOBUTENONES; ALKYNE; ACTIVATION; CHEMISTRY; INSERTION; OLEFINS;

D O I：

10.1002/anie.201503461

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic intermolecular proximal C1C2 cleavage of benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo-, regio- and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons.

引用

页码：9537 / 9541

页数：5

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