Adipose-Derived Stem Cell Treatments and Formulations

被引：21
作者：
Di Matteo, Berardo [1 ,2 ]
El Araby, Mohamed Marzouk [1 ,2 ]
D'Angelo, Alessandro [3 ]
Iacono, Francesco [1 ,2 ]
Nannini, Alessandra [1 ,2 ]
Vitale, Nicole Danilo [1 ,2 ]
Marcacci, Maurilio [1 ,2 ]
Respizzi, Stefano [1 ,2 ]
Kon, Elizaveta [1 ,2 ]
机构：
[1] Humanitas Univ, Dept Biomed Sci, Via Manzoni 113, I-20089 Milan, Italy
[2] Humanitas Clin & Res Ctr, Via Manzoni 56, I-20089 Milan, Italy
[3] Azienda Osped Univ Citta Salute & Sci, CTO Hosp, Dept Orthopaed Traumatol & Rehabil, Via Zuretti 29, I-10126 Turin, Italy
来源：
CLINICS IN SPORTS MEDICINE | 2019年 / 38卷 / 01期
关键词：
Stem cells; Adipose-derived mesenchymal stem cells; Stromal vascular fraction; Intra-articular injection; Cartilage; Osteoarthritis; PLATELET-RICH PLASMA; ARTICULAR-CARTILAGE DEFECT; MESENCHYMAL STEM; BONE-MARROW; INTRAARTICULAR INJECTION; KNEE; TISSUE; OSTEOARTHRITIS; REGENERATION; REPAIR;
D O I：
10.1016/j.csm.2018.08.004
中图分类号：
G8 [体育];
学科分类号：
04 ; 0403 ;
摘要：
This article analyzes the current literature on the use of adipose-derived stem cells (ASCs) to evaluate the available evidence regarding their therapeutic potential in the treatment of cartilage pathology. Seventeen articles were included and analyzed, showing that there is overall a lack of high quality evidence concerning the use of ASCs. Most trials are case series with short-term evaluation. The most adopted approach consists of an intra-articular injection of the stromal vascular fraction (SVF) rather than the expanded cells. Based on the available data, no specific preparation method or formulation could be considered as the preferred choice in clinical practice.
引用
收藏
页码：61 / +
页数：19
相关论文
共 53 条
  • [1] Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    Aigner, Thomas
    Fundel, Katrin
    Saas, Joachim
    Gebhard, Pia M.
    Haag, Jochen
    Weiss, Tilo
    Zien, Alexander
    Obermayr, Franz
    Zimmer, Ralf
    Bartnik, Eckart
    [J]. ARTHRITIS AND RHEUMATISM, 2006, 54 (11): : 3533 - 3544
  • [2] Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis (Cx611): results of a multicentre, dose escalation, randomised, single-blind, placebo-controlled phase Ib/Ila clinical trial
    Alvaro-Gracia, Jose M.
    Jover, Juan A.
    Garcia-Vicuna, Rosario
    Carreno, Luis
    Alonso, Alberto
    Marsal, Sara
    Blanco, Francisco
    Martinez-Taboada, Victor M.
    Taylor, Peter
    Martin-Martin, Cristina
    DelaRosa, Olga
    Tagarro, Ignacio
    Diaz-Gonzalez, Federico
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 (01) : 196 - 202
  • [3] Yield of human adipose-derived adult stem cells from liposuction aspirates
    Aust, L
    Devlin, B
    Foster, SJ
    Halvorsen, YDC
    Hicok, K
    du Laney, T
    Sen, A
    Willingmyre, GD
    Gimble, JM
    [J]. CYTOTHERAPY, 2004, 6 (01) : 7 - 14
  • [4] RETRACTED: Intra-articular injection in the knee of adipose derived stromal cells (stromal vascular fraction) and platelet rich plasma for osteoarthritis (Retracted Article)
    Bansal, Himanshu
    Comella, Kristin
    Leon, Jerry
    Verma, Poonam
    Agrawal, Diwaker
    Koka, Prasad
    Ichim, Thomas
    [J]. JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15
  • [5] Adult mesenchymal stem cells for tissue engineering versus regenerative medicine
    Caplan, Arnold I.
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 2007, 213 (02) : 341 - 347
  • [6] Repair of articular cartilage defect in non-weight bearing areas using adipose derived stem cells loaded polyglycolic acid mesh
    Cui, Lei
    Wu, Yaohao
    Cen, Lian
    Zhou, Heng
    Yin, Shuo
    Liu, Guangpeng
    Liu, Wei
    Cao, Yilin
    [J]. BIOMATERIALS, 2009, 30 (14) : 2683 - 2693
  • [7] Human Adipose-Derived Stromal Cells Efficiently Support Hematopoiesis In Vitro and In Vivo: A Key Step for Therapeutic Studies
    De Toni, Fabienne
    Poglio, Sandrine
    Ben Youcef, Aissa
    Cousin, Beatrice
    Pflumio, Francoise
    Bourin, Philippe
    Casteilla, Louis
    Laharrague, Patrick
    [J]. STEM CELLS AND DEVELOPMENT, 2011, 20 (12) : 2127 - 2138
  • [8] Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model
    Desando, Giovanna
    Cavallo, Carola
    Sartoni, Federica
    Martini, Lucia
    Parrilli, Annapaola
    Veronesi, Francesca
    Fini, Milena
    Giardino, Roberto
    Facchini, Andrea
    Grigolo, Brunella
    [J]. ARTHRITIS RESEARCH & THERAPY, 2013, 15 (01)
  • [9] Mesenchymal stem cells in tissue repair
    DiMarino, Amy M.
    Caplan, Arnold I.
    Bonfield, Tracey L.
    [J]. FRONTIERS IN IMMUNOLOGY, 2013, 4
  • [10] Filardo Giuseppe, 2013, Joints, V1, P112
123456