On the armament and appearances of human myeloid-derived suppressor cells

被引：167

作者：

Poschke, Isabel ^{[1
]}

Kiessling, Rolf ^{[1
]}

机构：

[1] Karolinska Inst, Dept Pathol & Oncol, Canc Ctr Karolinska R8 01, Stockholm, Sweden

来源：

CLINICAL IMMUNOLOGY | 2012年 / 144卷 / 03期

关键词：

MDSC; Cancer; Autoimmunity; Transplantation; CD4(+) T-CELLS; DENDRITIC CELL; IMMUNE SUPPRESSION; CANCER-PATIENTS; ARGINASE-I; IMMUNOSUPPRESSIVE ACTIVITY; HEPATOCELLULAR-CARCINOMA; HEMATOPOIETIC STEM; ANTITUMOR IMMUNITY; HYDROGEN-PEROXIDE;

D O I：

10.1016/j.clim.2012.06.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Myeloid-derived suppressor cells (MDSC) have frequently been observed in patients with cancer. This heterogeneous population of myeloid cells can exert potent suppression of lymphocyte function and thereby poses a significant hurdle to natural or therapeutically induced anti-tumor immunity. On the other hand, the natural function of MDSC is not yet well understood and their role in infection, inflammation and autoimmune disease is still puzzling. Understanding MDSC biology will provide the tools necessary for therapeutic targeting of this population, but also permit exploitation of their strong tolerogenic function in the treatment of inflammatory conditions and the prevention of graft rejection. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：250 / 268

页数：19

共 150 条

[1] Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
Almand, B
Clark, JI
Nikitina, E
van Beynen, J
English, NR
Knight, SC
Carbone, DP
Gabrilovich, DI
[J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (01) : 678 - 689
[2] ALRAMADI BK, 1991, J IMMUNOL, V146, P2737
[3] Tcr ζ-chain downregulation:: Curtailing an excessive inflammatory immune response
Baniyash, M
[J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (09) : 675 - 687
[4] Extrinsic regulators of epithelial tumor progression: metalloproteinases
Bergers, G
Coussens, LM
[J]. CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (01) : 120 - 127
[5] Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
Bergers, G
Brekken, R
McMahon, G
Vu, TH
Itoh, T
Tamaki, K
Tanzawa, K
Thorpe, P
Itohara, S
Werb, Z
Hanahan, D
[J]. NATURE CELL BIOLOGY, 2000, 2 (10) : 737 - 744
[6] Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties
Brandau, Sven
Trellakis, Sokratis
Bruderek, Kirsten
Schmaltz, Dominik
Steller, Gabriele
Elian, Motaz
Suttmann, Henrik
Schenck, Marcus
Welling, Juergen
Zabel, Peter
Lang, Stephan
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2011, 89 (02) : 311 - 317
[7] Increased Level of both CD4+FOXP3+ Regulatory T Cells and CD14+HLA-DR-/low Myeloid-Derived Suppressor Cells and Decreased Level of Dendritic Cells in Patients with Multiple Myeloma
Brimnes, M. K.
Vangsted, A. J.
Knudsen, L. M.
Gimsing, P.
Gang, A. O.
Johnsen, H. E.
Svane, I. M.
[J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 72 (06) : 540 - 547
[8] IL-4-induced arginase 1 suppresses alloreactive T cells in tumor-bearing mice
Bronte, V
Serafini, P
De Santo, C
Marigo, I
Tosello, V
Mazzoni, A
Segal, DM
Staib, C
Lowel, M
Sutter, G
Colombo, MP
Zanovello, P
[J]. JOURNAL OF IMMUNOLOGY, 2003, 170 (01) : 270 - 278
[9] Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
Bronte, V
Kasic, T
Gri, G
Gallana, K
Borsellino, G
Marigo, I
Battistini, L
Iafrate, M
Prayer-Galetti, T
Pagano, F
Viola, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (08) : 1257 - 1268
[10] Nature of Myeloid Cells Expressing Arginase 1 in Peripheral Blood After Trauma
Bryk, Jodie A.
Popovic, Petar J.
Zenati, Mazen S.
Munera, Veronica
Pribis, John P.
Ochoa, Juan B.
[J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 2010, 68 (04): : 843 - 852

← 1 2 3 4 5 6 7 8 9 10 →