Relationships between Pulmonary Hypertension Risk, Clinical Profiles, and Outcomes in Dilated Cardiomyopathy

被引：10

作者：

Dziewiecka, Ewa ^{[1
]}

Wisniowska-Smialek, Sylwia ^{[1
]}

Karabinowska, Aleksandra ^{[1
]}

Holcman, Katarzyna ^{[1
]}

Gliniak, Matylda ^{[2
]}

Winiarczyk, Mateusz ^{[2
]}

Karapetyan, Arman ^{[2
]}

Kaciczak, Monika ^{[2
]}

Podolec, Piotr ^{[1
]}

Kostkiewicz, Magdalena ^{[1
]}

Hlawaty, Marta ^{[1
]}

Lesniak-Sobelga, Agata ^{[1
]}

Rubis, Pawel ^{[1
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Cardiac & Vasc Dis, John Paul II Hosp, PL-31202 Krakow, Poland

[2] Jagiellonian Univ, Coll Med, Dept Cardiac & Vasc Dis, John Paul II Hosp,Students Sci Grp, PL-31202 Krakow, Poland

来源：

JOURNAL OF CLINICAL MEDICINE | 2020年 / 9卷 / 06期

关键词：

pulmonary hypertension risk; echocardiography; dilated cardiomyopathy; PROGNOSTIC VALUE; HEART-FAILURE; EUROPEAN ASSOCIATION; AMERICAN SOCIETY; ARTERY PRESSURE; ECHOCARDIOGRAPHY; CARDIOLOGY; ADULTS; DEATH;

D O I：

10.3390/jcm9061660

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pulmonary hypertension (PH) in patients with heart failure (HF) contributes to a poorer prognosis. However, in those with dilated cardiomyopathy (DCM), the true prevalence and role of PH is unclear. Therefore, this study aimed to analyze the profile of DCM patients at various levels of PH risk, determined via echocardiography, and its impact on outcomes. The 502 DCM in- and out-patient records were retrospectively analyzed. Information on patient status was gathered after 45.9 +/- 31.3 months. Patients were divided into 3 PH-risk groups based on results from echocardiography measurements: low (L,n= 239, 47.6%), intermediate (I,n= 153, 30.5%), and high (H,n= 110, 21.9%). Symptom duration, atrial fibrillation, ventricular tachyarrhythmia, ejection fraction, right atrial area, and moderate or severe mitral regurgitation were found to be independently associated with PH risk. During the follow-up period, 83 (16.5%) DCM patients died: 29 (12.1%) in L, 31 (20.3%) in I, and 23 (20.9%) in H. L-patients had a significantly lower risk of all-cause death (L to H: HR 0.55 (95%CI 0.32-0.98),p= 0.01), while no differences in prognosis were found between I and H. In conclusion, over one in five DCM patients had a high PH risk, and low PH risk was associated with better prognoses.

引用

页数：12

共 40 条

[1] PULMONARY-HYPERTENSION PREDICTS MORTALITY AND MORBIDITY IN PATIENTS WITH DILATED CARDIOMYOPATHY [J].