Interaction Between Anionic Liposomes and Cationic Pyridylphenylene Dendrimers

Complexes of a cationic pyridylphenylene dendrimer with solid and fluid anionic liposomes are prepared. Adsorption of the dendrimer on the surface of liposomes causes the neutralization of their surface charge and enlargement of the dendrimer-liposome aggregates. In interacting with fluid liposomes, the dendrimer does not induce the transition of negatively charged lipid molecules from the inner monolayer into the outer one (flip-flop). The prepared liposome-dendrimer aggregates contain 80 dendrimer molecules per liposome.