The Change in Conjugated Linoleic Acid Concentration in Blood of Japanese Fed a Conjugated Linoleic Acid Diet

被引：21

作者：

Sato, Kenta ^{[1
]}

Shinohara, Nahoko ^{[1
]}

Honma, Taro ^{[1
]}

Ito, Junya ^{[1
]}

Arai, Tatsuya ^{[1
]}

Nosaka, Naohisa ^{[2
]}

Aoyama, Toshiaki ^{[2
]}

Tsuduki, Tsuyoshi ^{[1
]}

Ikeda, Ikuo ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr, Lab Food & Biomol Sci, Sendai, Miyagi 9818555, Japan

[2] Nisshin Oillio Grp Ltd, Cent Res Lab, Yokosuka, Kanagawa 2390832, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2011年 / 57卷 / 05期

关键词：

conjugated fatty acid; CLA; conjugated linoleic acid; metabolism; human; BODY-FAT MASS; LIPID-PEROXIDATION; OVERWEIGHT HUMANS; OBESE HUMANS; HUMAN SERUM; SUPPLEMENTATION; METABOLISM; HEALTHY; GROWTH; CELLS;

D O I：

10.3177/jnsv.57.364

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Conjugated linoleic acid (CLA) is a collective term used for fatty acids with a conjugated double bond that are geometrical and positional isomers of linoleic acid. Antiobesity and anti-cancer properties, an immunopotentiation effect, and promotion of bone formation by CLA have been shown in cell culture and animal studies. A mixture of 9c11t- and 10t12c-CLA is now used as a health food supplement after testing in clinical trials. These trials focused on improvement of lipid metabolism by CLA, whereas few studies have examined absorption and metabolism of CLA in humans. In addition, there is no report concerning absorption and metabolism of CLA in Japanese. This study was designed to examine CLA concentration in blood, the elimination rate of CLA, and metabolic differences between 9c11t-CLA and 10t12c-CLA in blood in Japanese who ingested CLA (about 2 g/d, equal weights of 9c11t-CLA and 10t12c-CLA) for 3 wk. Blood samples were collected 1 wk before the 3-wk period, on the first and last days of the period, and 1 wk after the end of the period, and the CLA concentration and distribution in blood were investigated. The CLA concentration in blood was significantly increased by CLA ingestion and reached 36 mu mol/L. The CLA concentration in blood one week after the intake period was significantly lower than that at the end of CLA intake. The 10t12c-CLA level in plasma decreased faster than that of 9c11t-CLA. This suggests faster metabolism (fatty acid beta oxidation) of 10t12c-CLA compared with 9c11t-CLA.

引用

页码：364 / 371

页数：8

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