Early general movements and brain magnetic resonance imaging at term-equivalent age in infants born <30 weeks' gestation

被引：23

作者：

Olsen, Joy E. ^{[1
,2
]}

Brown, Nisha C. ^{[1
]}

Eeles, Abbey L. ^{[1
]}

Einspieler, Christa ^{[3
]}

Lee, Katherine J. ^{[1
,4
]}

Thompson, Deanne K. ^{[1
,4
]}

Anderson, Peter J. ^{[1
,4
]}

Cheong, Jeanie L. Y. ^{[1
,2
,5
]}

Doyle, Lex W. ^{[1
,2
,5
]}

Spittle, Alicia J. ^{[1
,2
,6
]}

机构：

[1] Royal Childrens Hosp, Murdoch Childrens Res Inst, Victorian Infant Brain Studies, Clin Sci, Flemington Rd, Parkville, Vic 3052, Australia

[2] Royal Womens Hosp, Newborn Res, 7th Floor,20 Flemington Rd, Parkville, Vic 3052, Australia

[3] Med Univ Graz, Inst Physiol, Ctr Physiol Med, Univ Str 15, A-8010 Graz, Austria

[4] Univ Melbourne, Royal Childrens Hosp, Dept Paediat, Flemington Rd, Parkville, Vic 3052, Australia

[5] Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, 20 Flemington Rd, Parkville, Vic 3052, Australia

[6] Univ Melbourne, Physiotherapy Dept, 7th Floor,Alan Gilbert Bldg,Grattan St, Parkville, Vic 3052, Australia

来源：

EARLY HUMAN DEVELOPMENT | 2016年 / 101卷

基金：

英国医学研究理事会;

关键词：

General movements; Magnetic resonance imaging; Preterm infant; Neurodevelopmental assessment; WHITE-MATTER PATHOLOGY; PRETERM INFANTS; CEREBRAL-PALSY; BIRTH; PREDICTORS; INTERVENTION; CHILDREN; INJURY; MRI;

D O I：

10.1016/j.earlhumdev.2016.06.009

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Background: Neurodevelopmental assessments and brain magnetic resonance imaging (MRI) at term equivalent age (TEA) predict developmental outcomes in preterm infants. However, the relationship between neurodevelopment prior to term and cerebral structure is currently unknown. Aims: To examine the relationships between General Movements (GMs) assessed from birth to TEA and brain MRI at TEA in infants born <30 weeks' gestation. Study design: Prospective cohort study. GMs (categorised as 'normal' or 'abnormal') were recorded weekly from birth to 32 weeks, and at 34 and 36 weeks' postmenstrual age. At TEA, GMs were assessed concurrently with brain MRI (using a validated scoring system). Subjects: 149 infants born <30 weeks' gestation were recruited from a tertiary hospital. Results: 103 infants had MRI at TEA and GMs recorded. Abnormal GMs prior to term were associated with cortical grey matter abnormality (p < 0.03), deep grey matter abnormality (p = 0.02) and increased interhemispheric distance (p < 0.02). Abnormal GMs at TEA (n = 55/90) were associated with more global brain abnormality (p < 0.01) and cortical grey matter abnormality (p = 0.01), and decreased transcerebellar diameter (p = 0.04) on concurrent brain MRI. Conclusions: Abnormal GMs both prior to term and at TEA were associated with more marked brain abnormality, and smaller brains at TEA. Abnormal GMs are an early marker of brain abnormalities in very preterm infants. (c) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：63 / 68

页数：6

共 33 条

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