Functionality of natural killer cells from end-stage cancer patients exposed to coherent electromagnetic fields

被引:10
|
作者
Evangelou, Angelos
Toliopoulos, Ioannis [2 ]
Giotis, Christos [3 ]
Metsios, Apostolos
Verginadis, Ioannis
Simos, Yannis
Havelas, Konstantinos
Hadziaivazis, Georgios
Karkabounas, Spyridon [1 ]
机构
[1] Univ Ioannina, Fac Med, Dept Physiol, Physiol Lab, GR-45110 Ioannina, Greece
[2] Konstantinion Res Ctr Mol Med & Biotechnol, Thessaloniki, Greece
[3] Gen Hosp Arta, Nephrol Clin, Arta, Greece
关键词
Natural killer cells; Flow cytometry; Coherent electromagnetic fields; Electromagnetic; resonance; MAGNETIC-FIELDS; FLOW-CYTOMETRY; TUMOR-GROWTH; WISTAR RATS; TOXICITY; CHEMOTHERAPY; ENHANCEMENT; LYMPHOCYTES; INHIBITION; SAFETY;
D O I
10.3109/15368378.2011.566776
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The main objective of our study is to investigate whether an enhancement of the immune system in end-stage cancer patients is achieved by exposure to coherent electromagnetic fields. For this reason, 15 end-stage cancer patients were exposed at low intensity, coherent electromagnetic fields at radiofrequencies ranging from 600 kHz--729 Hz, for 8 h/day, 6 days/week for 4 weeks. NKs number and cytotoxicity of NK T-lymphocytes versus K562 cancer cell line were estimated by flow cytometry, before and after exposure. Data showed that the exposure of the end-stage cancer patients to the coherent electromagnetic fields resulted in a significant increase of the number and the cytotoxicity of the NK T-lymphocytes against cancer cells, in all patients. Exposure to coherent EMFs at radiofrequencies increases the number and cytotoxicity of NK T-lymphocytes, which may contribute to the improvement of cancer patients' status.</.
引用
收藏
页码:46 / 56
页数:11
相关论文
共 50 条
  • [31] Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
    Hélène Cabanas
    Katsuhiko Muraki
    Natalie Eaton
    Cassandra Balinas
    Donald Staines
    Sonya Marshall-Gradisnik
    Molecular Medicine, 2018, 24
  • [32] Loss of Transient Receptor Potential Melastatin 3 ion channel function in natural killer cells from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
    Cabanas, Helene
    Muraki, Katsuhiko
    Eaton, Natalie
    Balinas, Cassandra
    Staines, Donald
    Marshall-Gradisnik, Sonya
    MOLECULAR MEDICINE, 2018, 24
  • [33] Ex vivo expansion of human peripheral blood natural killer cells and cytotoxic T lymphocytes from lung cancer patients
    Hoang Thi My Nhung
    Bui Viet Anh
    Truong Linh Huyen
    Doan Trung Hiep
    Chu Thi Thao
    Phung Nam Lam
    Nguyen Thanh Liem
    ONCOLOGY LETTERS, 2018, 15 (04) : 5730 - 5738
  • [34] Clinical-Scale Derivation of Natural Killer Cells From Human Pluripotent Stem Cells for Cancer Therapy
    Knorr, David A.
    Ni, Zhenya
    Hermanson, David
    Hexum, Melinda K.
    Bendzick, Laura
    Cooper, Laurence J. N.
    Lee, Dean A.
    Kaufman, Dan S.
    STEM CELLS TRANSLATIONAL MEDICINE, 2013, 2 (04) : 274 - 283
  • [35] Induction of chromosomal aberrations in human primary fibroblasts and immortalized cancer cells exposed to extremely-low-frequency electromagnetic fields
    Seyyedi, S. S.
    Mozdarani, H.
    Tavirani, M. Rezaei
    Heydari, S.
    IRANIAN JOURNAL OF RADIATION RESEARCH, 2010, 8 (01): : 25 - 29
  • [36] Use of sorafenib in two metastatic renal cell cancer patients with end-stage renal impairment undergoing replacement hemodialysis
    Ferraris, Elisa
    Di Cesare, Pamela
    Lasagna, Angioletta
    Paglino, Chiara
    Imarisio, Ilaria
    Porta, Camillo
    TUMORI JOURNAL, 2009, 95 (04): : 542 - 544
  • [37] Natural killer cells and interleukin-12 in patients with advanced cervical cancer under neoadjuvant chemotherapy
    Marana, HRC
    Andrade, JM
    Silva, JS
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1996, 29 (04) : 473 - 477
  • [38] The Prognostic Significance of Peripheral T-lymphocyte Subsets and Natural Killer Cells in Patients with Colorectal Cancer
    Qiu, Haibo
    Wu Xiao-Jun
    Zhou Zhi-Wei
    Chen Gong
    Wang Guo-Qiang
    Zhang Li-Yi
    Li Yuan-Fang
    Rajiv-Prasad, Keshari
    HEPATO-GASTROENTEROLOGY, 2009, 56 (94-95) : 1310 - 1315
  • [39] Perioperative cimetidine application modulates natural killer cells in patients with colorectal cancer: A randomized clinical study
    Bai Dejiao
    Yang Guoliang
    Yuan Hongying
    Li Yan
    Wang Kun
    Shao Hua
    Current Medical Science, 1999, 19 (4) : 300 - 303
  • [40] Perioperative Cimetidine Application Modulates Natural Killer Cells in Patients with Colorectal Cancer: A Randomized Clinical Study
    白德骄
    杨国梁
    袁宏银
    李雁
    王坤
    邵华
    JournalofTongjiMedicalUniversity, 1999, (04) : 300 - 303