Current status and prospects of antiplatelet therapy in percutaneous coronary intervention in Japan: Focus on adenosine diphosphate receptor inhibitors

被引：11

作者：

Ogawa, Hisao ^{[1
]}

Hokimoto, Seiji ^{[1
]}

Kaikita, Koichi ^{[1
]}

Yamamoto, Koichiro ^{[1
]}

Chitose, Tadasuke ^{[1
]}

Ono, Takamichi ^{[1
]}

Tsujita, Kenichi ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Fac Life Sci, Dept Cardiovasc Med, Kumamoto 8608556, Japan

来源：

JOURNAL OF CARDIOLOGY | 2011年 / 58卷 / 01期

关键词：

Cardiovascular disease; Platelet inhibitors; Thrombosis; Drug therapy; Adenosine diphosphate; ELEVATION MYOCARDIAL-INFARCTION; ASPIRIN-TREATED PATIENTS; PROTON PUMP INHIBITORS; INDUCED HEPATOTOXICITY; STENT IMPLANTATION; DIABETES-MELLITUS; AMERICAN-COLLEGE; HEALTHY CHINESE; ARTERY-DISEASE; DOUBLE-BLIND;

D O I：

10.1016/j.jjcc.2011.03.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Dual antiplatelet therapy with aspirin and clopidogrel is routinely used to prevent thrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI) in Japan. However, these agents have various limitations and some patients will experience further cardiovascular events. The purpose of this article is to review the antiplatelet agents currently used in patients undergoing PCI in Japan, to discuss the issues and limitations associated with these antiplatelet agents, and to characterize new antiplatelet agents currently under investigation in Japan. Particular emphasis is placed on the novel thienopyridine prasugrel, and the potential this drug has for overcoming the issues associated with other antiplatelet agents. (C) 2011 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.

引用

页码：6 / 17

页数：12

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