Recent advances in improving intranasal allergen-specific immunotherapy; focus on delivery systems and adjuvants

被引：8

作者：

Sadeghi, Mahvash ^{[1
,2
]}

Asadirad, Ali ^{[1
,3
]}

Koushki, Khadijeh ^{[4
]}

Shahbaz, Sanaz Keshavarz ^{[5
]}

Dehnavi, Sajad ^{[1
,2
]}

机构：

[1] Ahvaz Jundishapur Univ Med Sci, Fac Med, Dept Immunol, Ahvaz, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Student Res Comm, Ahvaz, Iran

[3] Ahvaz Jundishapur Univ Med Sci, Canc Petr & Environm Pollutants Res Ctr, Ahvaz, Iran

[4] Mayo Clin, Dept Radiat Oncol, Jacksonville, FL USA

[5] Qazvin Univ Med Sci, Res Inst Prevent Noncommunicable Dis, Cellular & Mol Res Ctr, Qazvin, Iran

来源：

INTERNATIONAL IMMUNOPHARMACOLOGY | 2022年 / 113卷

关键词：

Allergen -specific immunotherapy (AIT); intranasal immunotherapy (INIT); Delivery system; Adjuvant; Nanoparticles; OLIGOMANNOSE-COATED LIPOSOMES; LACTIC-ACID BACTERIA; REGULATORY T-CELLS; DRUG-DELIVERY; AIRWAY INFLAMMATION; GOLD NANOPARTICLES; IMMUNE-RESPONSE; EXTRACELLULAR VESICLES; PLGA NANOPARTICLES; INFLUENZA-VIRUS;

D O I：

10.1016/j.intimp.2022.109327

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allergen-specific Immunotherapy (AIT) is the main therapeutic strategy to control and treat allergic disorders. Intranasal Immunotherapy (INIT) was introduced as a needle-free, noninvasive, and efficient approach among various routes of allergen administration. Since direct exposure of nasal mucosa to allergen extracts could induce local and systemic reactions, recent studies focus on establishing novel formulations using various delivery systems and adjuvants to improve INIT efficacy. This review categorizes and describes natural and synthetic micro/nanoparticles such as chitosan, PLGA, liposome, exosome, and nano-emulation droplets used as delivery systems or immunomodulatory and immune-regulatory agents. Also, multiple microbial agents, including probiotics, mycobacterial and viral components, TLR ligands, and biologic agents, i.e., antibody fragments, recombinant cytokines, vitamin A, and pulsed dendritic cells (DCs), are other platforms that are discussed. In addition, future perspectives and proposed strategies to help INIT were provided.

引用

页数：13

共 157 条

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