Fasciola hepatica is associated with the failure to detect bovine tuberculosis in dairy cattle

被引：110

作者：

Claridge, Jen ^{[1
,2
]}

Diggle, Peter ^{[1
,2
,3
]}

McCann, Catherine M. ^{[1
,2
]}

Mulcahy, Grace ^{[4
]}

Flynn, Rob ^{[4
]}

McNair, Jim ^{[5
]}

Strain, Sam ^{[5
]}

Welsh, Michael ^{[5
]}

Baylis, Matthew ^{[1
,2
]}

Williams, Diana J. L. ^{[1
,2
]}

机构：

[1] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 7ZJ, Merseyside, England

[2] Univ Liverpool, Sch Vet Sci, Liverpool L69 7ZJ, Merseyside, England

[3] Univ Lancaster, Lancaster Med Sch, Lancaster LA1 4YB, England

[4] Univ Coll Dublin, Sch Vet Med, Dublin 4, Ireland

[5] Agri Food & Biosci Inst, Dept Bacteriol, Vet Sci Div, Belfast BT4 3SD, Antrim, North Ireland

来源：

NATURE COMMUNICATIONS | 2012年 / 3卷

基金：

英国生物技术与生命科学研究理事会;

关键词：

MYCOBACTERIUM-BOVIS; SPATIAL-DISTRIBUTION; IMMUNE-RESPONSES; GREAT-BRITAIN; INFECTION; ANTIGENS; ENGLAND; HERDS; WALES; BCG;

D O I：

10.1038/ncomms1840

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Bovine tuberculosis (BTB) is a significant and intractable disease of cattle caused by Mycobacterium bovis. In the United Kingdom, despite an aggressive eradication programme, the prevalence of BTB is increasing with an unexplained, exponential rise in cases year on year. Here we show in a study involving 3,026 dairy herds in England and Wales that there is a significant negative association between exposure to the common, ubiquitous helminth parasite, Fasciola hepatica and diagnosis of BTB. The magnitude of the single intradermal comparative cervical tuberculin test used to diagnose BTB is reduced in cattle experimentally co-infected with M. bovis and F. hepatica. We estimate an under-ascertainment rate of about one-third (95% confidence interval 27-38%) among our study farms, in the hypothetical situation of no exposure to F. hepatica. This finding may in part explain the continuing spread of BTB and the failure of the current eradication programme in the United Kingdom.

引用

页数：8

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