Antibody correlates of protection from SARS-CoV-2 reinfection prior to vaccination: A nested case-control within the SIREN study

被引：24

作者：

Atti, Ana ^{[1
]}

Insalata, Ferdinando ^{[1
]}

Carr, Edward J. ^{[2
]}

Otter, Ashley D. ^{[3
]}

Castillo-Olivares, Javier ^{[4
]}

Wu, Mary ^{[2
]}

Harvey, Ruth ^{[2
]}

Howell, Michael ^{[2
]}

Chan, Andrew ^{[4
]}

Lyall, Jonathan ^{[4
]}

Temperton, Nigel ^{[5
,6
]}

Cantoni, Diego ^{[5
,6
]}

da Costa, Kelly ^{[5
,6
]}

Nadesalingam, Angalee ^{[4
]}

Taylor-Kerr, Andrew ^{[1
]}

Hettiarachchi, Nipunadi ^{[1
]}

Tranquillini, Caio ^{[1
]}

Hewson, Jacqueline ^{[3
]}

Cole, Michelle J. ^{[1
]}

Foulkes, Sarah ^{[1
]}

Munro, Katie ^{[1
]}

Monk, Edward J. M. ^{[1
]}

Milligan, Iain D. ^{[1
]}

Linley, Ezra ^{[7
]}

Chand, Meera A. ^{[1
]}

Brown, Colin S. ^{[1
,8
]}

Islam, Jasmin ^{[1
]}

Semper, Amanda ^{[1
]}

Charlett, Andre ^{[1
,9
,10
]}

Heeney, Jonathan L. ^{[3
]}

Beale, Rupert ^{[2
]}

Zambon, Maria ^{[1
]}

Hopkins, Susan ^{[1
,8
]}

Brooks, Tim ^{[1
]}

Hall, Victoria ^{[1
,8
]}

机构：

[1] UK Hlth Secur Agcy, Smith Sq, London SW1P, England

[2] Francis Crick Inst, 1 Midland Rd, London NW1 1AT, England

[3] UK Hlth Secur Agcy, Salisbury SP4 0JG, Wilts, England

[4] Univ Cambridge, Dept Vet Med, Lab Viral Zoonot, Madingley Rd, Cambridge CB3 0ES, England

[5] Univ Greenwich, Medway Sch Pharm, Viral Pseudotype Unit, Cent Ave, Chatham ME4 4BF, Kent, England

[6] Univ Kent Medway, Medway Sch Pharm, Viral Pseudotype Unit, Cent Ave, Chatham ME4 4BF, Kent, England

[7] UK Hlth Secur Agcy, Manchester Royal Infirm, Oxford Rd, Manchester M13 9WL, Lancs, England

[8] Univ Oxford, Natl Inst Hlth Res, Hlth Protect Res NIHR Unit Healthcare Associated, Old Rd Campus, Oxford OX3 7BN, England

[9] Univ Bristol, NIHR Hlth Protect Res Unit Behav Sci & Evaluat, Publ Hlth England, Queens Rd, Bristol BS8 1QU, Avon, England

[10] London Sch Hyg & Trop Med, NIHR Hlth Protect Res Unit Immunisat, Publ Hlth England, Keppel St, London WC1E 7HT, England

来源：

JOURNAL OF INFECTION | 2022年 / 85卷 / 05期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

SARS-CoV-2; Neutralising antibodies; serology; Reinfection; Immunity; HEALTH-CARE WORKERS; INFECTION; COHORT; VOCS;

D O I：

10.1016/j.jinf.2022.09.004

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: To investigate serological differences between SARS-CoV-2 reinfection cases and contemporary controls, to identify antibody correlates of protection against reinfection.Methods: We performed a case-control study, comparing reinfection cases with singly infected individ-uals pre-vaccination, matched by gender, age, region and timing of first infection. Serum samples were tested for anti-SARS-CoV-2 spike (anti-S), anti-SARS-CoV-2 nucleocapsid (anti-N), live virus microneutral-isation (LV-N) and pseudovirus microneutralisation (PV-N). Results were analysed using fixed effect linear regression and fitted into conditional logistic regression models.Results: We identified 23 cases and 92 controls. First infections occurred before November 2020; re -infections occurred before February 2021, pre-vaccination. Anti-S levels, LV-N and PV-N titres were sig-nificantly lower among cases; no difference was found for anti-N levels. Increasing anti-S levels were associated with reduced risk of reinfection (OR 0 middot63, CI 0 middot47-0 middot85), but no association for anti-N levels (OR 0 middot88, CI 0 middot73-1 middot05). Titres > 40 were correlated with protection against reinfection for LV-N Wuhan (OR 0 middot02, CI 0 middot001-0 middot31) and LV-N Alpha (OR 0 middot07, CI 0 middot009-0 middot62). For PV-N, titres > 100 were associated with protection against Wuhan (OR 0 middot14, CI 0 middot03-0 middot64) and Alpha (0 middot06, CI 0 middot008-0 middot40).Conclusions: Before vaccination, protection against SARS-CoV-2 reinfection was directly correlated with anti-S levels, PV-N and LV-N titres, but not with anti-N levels. Detectable LV-N titres were sufficient for protection, whilst PV-N titres > 100 were required for a protective effect. Trial registration number: ISRCTN11041050Crown Copyright (c) 2022 Published by Elsevier Ltd on behalf of The British Infection Association. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

引用

页码：545 / 556

页数：12

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