Wavefront-Guided and Aspheric Ablation for Myopia One-Year Results of the Zyoptix Personalized Treatment Advanced Algorithm

center dot PURPOSE: To evaluate the visual outcome and change in higher-order aberrations (HOAs) 1 year post simultaneous wavefront-guided and aspheric photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK). center dot DESIGN: Prospective interventional case series. center dot METHODS: Consecutive myopic patients undergoing PRK (38 eyes of 23 patients) and LASIK (42 eyes of 25 patients) using the Technolas 217z100 excimer laser (Technolas Perfect Vision) in a private laser clinic were included. Main outcome measures were uncorrected distance visual acuity (UDVA), manifest refraction (MRSE), HOAs, and spherical aberration (Z(4)(0)). center dot RESULTS: At 1 year, 87% (32/37) of PRK eyes and 81% (30/37) of LASIK eyes had UDVA of 20/20 or better (P = .75). Mean +/- SD MRSE was -0.26 +/- 0.31 diopters (D) in the PRK and -0.16 +/- 0.34 D in the LASIK group (P = .222). There was no significant increase in total HOA root mean square (RMS) in the PRK group. Mean +/- SD total HOA RMS increased from 0.402 +/- 0.14 mu m to 0.496 +/- 0.17 mu m (P = .013) in the LASIK group at 1 year. Z4(0) increased from mean +/- SD -0.045 +/- 0.12 mu m to -0.109 +/- 0.15 mu m (P = .006, factor 2.42) in the PRK group and did not significantly increase in the LASIK group (mean +/- SD -0.16 +/- 0.17 mu m to -0.17 +/- 0.15 mu m (P = .469, factor 1.08) at 6 mm pupil. center dot CONCLUSIONS: Visual outcome was excellent in both treatment groups. HOAs were still increased following LASIK by a factor of 1.23 but not PRK. Z4(0) was not induced by LA SIK with the treatment algorithm but was negatively induced in PRK eyes. (Am J Ophthalmol 2012;153:1169-1177. (C) 2012 by Elsevier Inc. All rights reserved.)