Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

被引：10

作者：

Tayyar, Ahter Tanay ^{[1
,5
]}

Tayyar, Ahmet ^{[2
]}

Kozali, Sukran ^{[3
]}

Karakus, Resul ^{[3
]}

Eser, Ahmet ^{[3
]}

Yayla, Cigdem Abide ^{[3
]}

Yalcin, Emel Tugce ^{[3
]}

Dag, Ismail ^{[4
]}

Eroglu, Mustafa ^{[3
]}

机构：

[1] Acibadem Univ, Fac Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Istanbul, Turkey

[2] Medipol Univ, Fac Med, Dept Obstet & Gynecol, Istanbul, Turkey

[3] Hlth Sci Univ, Zeynep Kamil Matern & Childrens Training & Res Ho, Dept Obstet & Gynecol, Istanbul, Turkey

[4] Eyup State Hosp, Dept Clin Biochem, Istanbul, Turkey

[5] Acibadem Maslak Hastanesi, Buyukdere Caddesi 40, TR-34457 Istanbul, Turkey

来源：

HYPERTENSION IN PREGNANCY | 2019年 / 38卷 / 01期

关键词：

preeclampsia; oxidative stress; sestrin; 2; LOWERS BLOOD-PRESSURE; OXIDATIVE STRESS; AGONISTIC AUTOANTIBODIES; HYPERTENSION; RECEPTOR; INDUCTION; PREGNANCY; OXYGEN;

D O I：

10.1080/10641955.2018.1540702

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = -.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.

引用

页码：13 / 19

页数：7

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