Maternal serum sestrin 2 levels in preeclampsia and their relationship with the severity of the disease

被引：10
|
作者：
Tayyar, Ahter Tanay [1 ,5 ]
Tayyar, Ahmet [2 ]
Kozali, Sukran [3 ]
Karakus, Resul [3 ]
Eser, Ahmet [3 ]
Yayla, Cigdem Abide [3 ]
Yalcin, Emel Tugce [3 ]
Dag, Ismail [4 ]
Eroglu, Mustafa [3 ]
机构：
[1] Acibadem Univ, Fac Med, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Istanbul, Turkey
[2] Medipol Univ, Fac Med, Dept Obstet & Gynecol, Istanbul, Turkey
[3] Hlth Sci Univ, Zeynep Kamil Matern & Childrens Training & Res Ho, Dept Obstet & Gynecol, Istanbul, Turkey
[4] Eyup State Hosp, Dept Clin Biochem, Istanbul, Turkey
[5] Acibadem Maslak Hastanesi, Buyukdere Caddesi 40, TR-34457 Istanbul, Turkey
来源：
HYPERTENSION IN PREGNANCY | 2019年 / 38卷 / 01期
关键词：
preeclampsia; oxidative stress; sestrin; 2; LOWERS BLOOD-PRESSURE; OXIDATIVE STRESS; AGONISTIC AUTOANTIBODIES; HYPERTENSION; RECEPTOR; INDUCTION; PREGNANCY; OXYGEN;
D O I：
10.1080/10641955.2018.1540702
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective: To investigate sestrin 2 (SESN2) levels in preeclampsia (PE) cases and uncomplicated pregnancies. Methods: Cross-sectional study including 26 pregnant women with PE, 24 with severe-PE, and 30 randomly selected healthy pregnant women. Results: The mean arterial pressure, severe proteinuria, number of HELLP syndrome cases, and serum SESN2 levels in the severe PE group were significantly higher than those in the other groups (p < 0.001, p < 0.001, p = 0.006, and p = 0.004, respectively). Negative correlation was found between the birth interval (r = -.262, p = 0.019) and the SESN2 level. Conclusion: SESN2 seems to play a role in the pathophysiology of PE, especially in severe PE cases.
引用
收藏
页码：13 / 19
页数：7
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