The burden of hypertension, diabetes mellitus, and cardiovascular risk factors among adult Malawians in HIV care: consequences for integrated services

被引：80

作者：

Divala, Oscar H. ^{[1
]}

Amberbir, Alemayehu ^{[1
]}

Ismail, Zahra ^{[2
]}

Beyene, Teferi ^{[1
]}

Garone, Daniela ^{[1
]}

Pfaff, Colin ^{[1
]}

Singano, Victor ^{[1
]}

Akello, Harriet ^{[1
]}

Joshua, Martias ^{[3
]}

Nyirenda, Moffat J. ^{[4
]}

Matengeni, Alfred ^{[1
]}

Berman, Josh ^{[1
]}

Mallewa, Jane ^{[4
]}

Chinomba, Gift S. ^{[5
]}

Kayange, Noel ^{[4
]}

Allain, Theresa J. ^{[4
]}

Chan, Adrienne K. ^{[1
]}

Sodhi, Sumeet K. ^{[1
,6
]}

van Oosterhout, Joep J. ^{[1
,4
]}

机构：

[1] Dignitas Int, POB 1071, Zomba, Malawi

[2] Pirimiti Rural Hosp, Pirimiti, Malawi

[3] Zomba Cent Hosp, Minist Hlth, Zomba, Malawi

[4] Coll Med, Dept Med, Blantyre, Malawi

[5] Dist Hlth Off, Minist Hlth, Zomba, Malawi

[6] Univ Hlth Network, Toronto Western Hosp, Toronto, ON, Canada

来源：

BMC PUBLIC HEALTH | 2016年 / 16卷

基金：

加拿大健康研究院;

关键词：

HIV; Hypertension; Diabetes; Malawi; Antiretroviral; Integrated; Cardiovascular; Africa; ANTIRETROVIRAL THERAPY; DISEASE;

D O I：

10.1186/s12889-016-3916-x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Hypertension and diabetes prevalence is high in Africans. Data from HIV infected populations are limited, especially from Malawi. Integrating care for chronic non-communicable co-morbidities in well-established HIV services may provide benefit for patients by preventing multiple hospital visits but will increase the burden of care for busy HIV clinics. Methods: Cross-sectional study of adults (>= 18 years) at an urban and a rural HIV clinic in Zomba district, Malawi, during 2014. Hypertension and diabetes were diagnosed according to stringent criteria. Proteinuria, non-fasting lipids and cardio/cerebro-vascular disease (CVD) risk scores (Framingham and World Health Organization/International Society for Hypertension) were determined. The association of patient characteristics with diagnoses of hypertension and diabetes was studied using multivariable analyses. We explored the additional burden of care for integrated drug treatment of hypertension and diabetes in HIV clinics. We defined that burden as patients with diabetes and/or stage II and III hypertension, but not with stage I hypertension unless they had proteinuria, previous stroke or high Framingham CVD risk. Results: Nine hundred fifty-two patients were enrolled, 71.7% female, median age 43.0 years, 95.9% on antiretroviral therapy (ART), median duration 47.7 months. Rural and urban patients' characteristics differed substantially. Hypertension prevalence was 23.7% (95%-confidence interval 21.1-26.6; rural 21.0% vs. urban 26.5%; p = 0.047), of whom 59.9% had stage I (mild) hypertension. Diabetes prevalence was 4.1% (95%-confidence interval 3.0-5.6) without significant difference between rural and urban settings. Prevalence of proteinuria, elevated total/highdensity lipoprotein-cholesterol ratio and high CVD risk score was low. Hypertension diagnosis was associated with increasing age, higher body mass index, presence of proteinuria, being on regimen zidovudine/lamivudine/nevirapine and inversely with World Health Organization clinical stage at ART initiation. Diabetes diagnosis was associated with higher age and being on non-standard first-line or second-line ART regimens. Conclusion: Among patients in HIV care 26.6% had hypertension and/or diabetes. Close to two-thirds of hypertension diagnoses was stage I and of those few had an indication for antihypertensive pharmacotherapy. According to our criteria, 13.0% of HIV patients in care required drug treatment for hypertension and/or diabetes.

引用

页码：1 / 11

页数：11

共 24 条

[1]

[Anonymous], 2009, WAIST CIRCUMFERENCE

[2] Blood cholesterol screening - Influence of fasting state on cholesterol results and management decisions [J].