Separation of platinum(II) anti-tumour drugs by micellar electrokinetic capillary chromatography

Micellar electrokinetic capillary chromatography was used for the separation of platinum anti-tumour drugs in aqueous solutions. With the use of sodium dodecyl sulfate (SDS) the neutral drugs cisplatin, carboplatin and lobaplatin and charged hydrolysis products could be separated very easily in only one run. The pH of buffer solution, SDS concentration, applied voltage and injection conditions were optimized. The limit of detection and linearity for the determination of each complex were determined. The developed method was used for stability measurements of the complexes in solution.