Tumor Promotion via Injury- and Death-Induced Inflammation

被引：226

作者：

Kuraishy, Ali ^{[1
,2
]}

Karin, Michael ^{[1
,2
]}

Grivennikov, Sergei I. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Sch Med, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Lab Gene Regulat & Signal Transduct, Sch Med, Dept Pathol, La Jolla, CA 92093 USA

来源：

IMMUNITY | 2011年 / 35卷 / 04期

关键词：

NF-KAPPA-B; ENDOTHELIAL GROWTH-FACTOR; COLITIS-ASSOCIATED CANCER; SQUAMOUS-CELL CARCINOMA; NECROSIS-FACTOR-ALPHA; HEPATOCELLULAR-CARCINOMA; STEM-CELLS; TNF-ALPHA; COLORECTAL-CANCER; STAT3; ACTIVATION;

D O I：

10.1016/j.immuni.2011.09.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inhibition of programmed cell death is considered to be a major aspect of tumorigenesis. Indeed, several key oncogenic transcription factors, such as NF-kappa B and STAT3, exert their tumor-promoting activity at least in part through upregulation of survival genes. However, many cancers develop in response to chronic tissue injury, in which the resulting cell death increases the tumorigenic potential of the neighboring cells. In this review, we discuss a resolution to this paradox based on cell death-mediated induction of tumor promoting inflammatory cytokines, which enhance cell survival and trigger compensatory proliferation in response to tissue injury.

引用

页码：467 / 477

页数：11

共 124 条

[1] B-cell-derived lymphotoxin promotes castration-resistant prostate cancer [J].

Ammirante, Massimo ;

Luo, Jun-Li ;

Grivennikov, Sergei ;

Nedospasov, Sergei ;

Karin, Michael .

NATURE, 2010, 464 (7286) :302-U187

[2] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis [J].

Andreu, Pauline ;

Johansson, Magnus ;

Affara, Nesrine I. ;

Pucci, Ferdinando ;

Tan, Tingting ;

Junankar, Simon ;

Korets, Lidiya ;

Lam, Julia ;

Tawfik, David ;

DeNardo, David G. ;

Naldini, Luigi ;

de Visser, Karin E. ;

De Palma, Michele ;

Coussens, Lisa M. .

CANCER CELL, 2010, 17 (02) :121-134

[3] The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy [J].

Apetoh, Lionel ;

Ghiringhelli, Francois ;

Tesniere, Antoine ;

Criollo, Alfredo ;

Ortiz, Carla ;

Lidereau, Rosette ;

Mariette, Christophe ;

Chaput, Nathalie ;

Mira, Jean-Paul ;

Delaloge, Suzette ;

Andre, Fabrice ;

Tursz, Thomas ;

Kroemer, Guido ;

Zitvogel, Laurence .

IMMUNOLOGICAL REVIEWS, 2007, 220 :47-59

[4] Tumour necrosis factor and cancer [J].

Balkwill, Frances .

NATURE REVIEWS CANCER, 2009, 9 (05) :361-371

[5] The Role of Vascular Endothelial Growth Factor in Wound Healing [J].

Bao, Philip ;

Kodra, Arber ;

Tomic-Canic, Marjana ;

Golinko, Michael S. ;

Ehrlich, H. Paul ;

Brem, Harold .

JOURNAL OF SURGICAL RESEARCH, 2009, 153 (02) :347-358

[6] Tissue repair and stem cell renewal in carcinogenesis [J].

Beachy, PA ;

Karhadkar, SS ;

Berman, DM .

NATURE, 2004, 432 (7015) :324-331

[7] TGF-β suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling [J].

Becker, C ;

Fantini, MC ;

Schramm, C ;

Lehr, HA ;

Wirtz, S ;

Nikolaev, A ;

Burg, J ;

Strand, S ;

Kiesslich, R ;

Huber, S ;

Ito, H ;

Nishimoto, N ;

Yoshizaki, K ;

Nishimoto, N ;

Galle, PR ;

Blessing, M ;

Rose-John, S ;

Neurath, MF .

IMMUNITY, 2004, 21 (04) :491-501

[8] TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer [J].

Bettermann, Kira ;

Vucur, Mihael ;

Haybaeck, Johannes ;

Koppe, Christiane ;

Janssen, Joern ;

Heymann, Felix ;

Weber, Achim ;

Weiskirchen, Ralf ;

Liedtke, Christian ;

Gassler, Nikolaus ;

Mueller, Michael ;

de Vos, Rita ;

Wolf, Monika Julia ;

Boege, Yannick ;

Seleznik, Gitta Maria ;

Zeller, Nicolas ;

Erny, Daniel ;

Fuchs, Thomas ;

Zoller, Stefan ;

Cairo, Stefano ;

Buendia, Marie-Annick ;

Prinz, Marco ;

Akira, Shizuo ;

Tacke, Frank ;

Heikenwalder, Mathias ;

Trautwein, Christian ;

Luedde, Tom .

CANCER CELL, 2010, 17 (05) :481-496

[9] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].

Bollrath, Julia ;

Phesse, Toby J. ;

von Burstin, Vivian A. ;

Putoczki, Tracy ;

Bennecke, Moritz ;

Bateman, Trudie ;

Nebelsiek, Tim ;

Lundgren-May, Therese ;

Canli, Oezge ;

Schwitalla, Sarah ;

Matthews, Vance ;

Schmid, Roland M. ;

Kirchner, Thomas ;

Arkan, Melek C. ;

Ernst, Matthias ;

Greten, Florian R. .

CANCER CELL, 2009, 15 (02) :91-102

[10] Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation [J].

Bornstein, Sophia ;

White, Ruth ;

Malkoski, Stephen ;

Oka, Masako ;

Han, Gangwen ;

Cleaver, Timothy ;

Reh, Douglas ;

Andersen, Peter ;

Gross, Neil ;

Olson, Susan ;

Deng, Chuxia ;

Lu, Shi-Long ;

Wang, Xiao-Jing .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (11) :3408-3419

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