Exosomes and mimics as novel delivery platform for cancer therapy

被引：20
作者：
Yang, Fuxu [1 ,2 ]
Wang, Mingyue [2 ,3 ,4 ]
Guan, Xingang [1 ]
机构：
[1] Taizhou Univ, Sch Med, Dept Basic Med, Taizhou, Peoples R China
[2] Beihua Univ, Sch Med Technol, Key Lab Pharmaceut & Bioengn, Jilin, Peoples R China
[3] First Hosp Jilin Univ, Ctr Reprod Med, Changchun, Peoples R China
[4] First Hosp Jilin Univ, Ctr Prenatal Diag, Changchun, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2022年 / 13卷
关键词：
exosome; cancer therapy; nanovesicle; drug delivery; tumor targeting; MEMBRANE-COATED NANOPARTICLES; EXTRACELLULAR VESICLES; TARGETED DELIVERY; GENE-THERAPY; DOXORUBICIN; BREAST; INHIBIT; IDENTIFICATION; PROLIFERATION; NANOVESICLES;
D O I：
10.3389/fphar.2022.1001417
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Exosomes are nano-sized biological extracellular vesicles transmitting information between cells and constituting a new intercellular communication mode. Exosomes have many advantages as an ideal drug delivery nanocarrier, including good biocompatibility, permeability, low toxicity, and low immunogenicity. Recently, exosomes have been used to deliver chemotherapeutic agents, natural drugs, nucleic acid drugs, and other antitumor drugs to treat many types of tumors. Due to the limited production of exosomes, synthetic exosome-mimics have been developed as an ideal platform for drug delivery. This review summarizes recent advances in the application of exosomes and exosome-mimics delivering therapeutic drugs in treating cancers.
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页数：9
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