Synthesis of Fluorinated and Non-Fluorinated Bicyclic Amidines through Ring-Closing Metathesis

被引：4
|
作者：
Cunat, Ana C. [1 ]
Flores, Sonia [2 ]
Oliver, Judit [1 ]
Fustero, Santos [2 ,3 ]
机构：
[1] Univ Valencia, Dept Quim Organ, Fac Quim, E-46100 Valencia, Spain
[2] Univ Valencia, Fac Farm, Dept Quim Organ, Valencia 46100, Spain
[3] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 36期
关键词：
Amidines; Nitrogen heterocycles; Metathesis; Fluorine; ASYMMETRIC-SYNTHESIS; EFFICIENT; PHARMACEUTICALS; ISOMERIZATION; HETEROCYCLES; ACTIVATION; CHEMISTRY; PATHWAY; PROFILE; ENTRY;
D O I：
10.1002/ejoc.201101091
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for the synthesis of fluorinated and non-fluorinated imidazoazepines by a ring-closing metathesis reaction as the key step is described. The influence of the fluorine atoms on the preparation of these bicyclic systems is also studied.
引用
收藏
页码：7317 / 7323
页数：7
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