Synthesis of Fluorinated and Non-Fluorinated Bicyclic Amidines through Ring-Closing Metathesis

被引：4

作者：

Cunat, Ana C. ^{[1
]}

Flores, Sonia ^{[2
]}

Oliver, Judit ^{[1
]}

Fustero, Santos ^{[2
,3
]}

机构：

[1] Univ Valencia, Dept Quim Organ, Fac Quim, E-46100 Valencia, Spain

[2] Univ Valencia, Fac Farm, Dept Quim Organ, Valencia 46100, Spain

[3] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 2011卷 / 36期

关键词：

Amidines; Nitrogen heterocycles; Metathesis; Fluorine; ASYMMETRIC-SYNTHESIS; EFFICIENT; PHARMACEUTICALS; ISOMERIZATION; HETEROCYCLES; ACTIVATION; CHEMISTRY; PATHWAY; PROFILE; ENTRY;

D O I：

10.1002/ejoc.201101091

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for the synthesis of fluorinated and non-fluorinated imidazoazepines by a ring-closing metathesis reaction as the key step is described. The influence of the fluorine atoms on the preparation of these bicyclic systems is also studied.

引用

页码：7317 / 7323

页数：7

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