Bi-modal near-infrared fluorescence and ultrasound imaging via a transparent ultrasound transducer for sentinel lymph node localization

被引:16
|
作者
Park, Jeongwoo [1 ,2 ,3 ,4 ]
Park, Byullee [1 ,2 ,3 ,4 ]
Yong, Uijung [1 ,2 ,3 ,4 ]
Ahn, Joongho [1 ,2 ,3 ,4 ]
Kim, Jin Young [1 ,2 ,3 ,4 ]
Kim, Hyung Ham [1 ,2 ,3 ,4 ]
Jang, Jinah [1 ,2 ,3 ,4 ]
Kim, Chulhong [1 ,2 ,3 ,4 ]
机构
[1] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Dept Elect Engn, Pohang, South Korea
[2] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Dept Convergence IT Engn, Pohang, South Korea
[3] Pohang Univ Sci & Technol, Sch Interdisciplinary Biosci & Bioengn, Dept Mech Engn, Pohang, South Korea
[4] Pohang Univ Sci & Technol, Med Device Innovat Ctr, Pohang, South Korea
关键词
BREAST-CANCER; BIOPSY; GUIDANCE; PROBE;
D O I
10.1364/OL.446041
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
Sentinel lymph node biopsy with an indocyanine green-based near-infrared fluorescence imaging system avoids the shortcomings of using a radioisotope or a combination of a blue dye and a radioactive tracer. To improve surgical precision, recent research has provided a depth profile of the sentinel lymph node by fusing fluorescence and ultrasound imaging. Here, we present a combined near-infrared fluorescence and ultrasound imaging system based on a transparent ultrasound transducer. The transparent ultrasound transducer enables seamless coaxial alignment of the fluorescence and ultrasound beam paths, allowing bi-modal observation of a single region of interest. Further, we demonstrate that the sentinel lymph node of mice injected with indocyanine green can be successfully localized and dissected based on information from the bi-modal imaging system. (C) 2022 Optica Publishing Group
引用
收藏
页码:393 / 396
页数:4
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