A One-Pot Synthesis of Symmetrical and Unsymmetrical Dipeptide Ureas

被引：4
作者：
Abou Fayad, Antoine [1 ,2 ]
Pubill-Ulldemolins, Cristina [1 ]
Sharma, Sunil V. [1 ]
Day, David [2 ]
Goss, Rebecca J. M. [1 ]
机构：
[1] Univ St Andrews, Sch Chem, St Andrews KY16 9ST, Fife, Scotland
[2] Univ E Anglia, Sch Chem, Norwich NR4 7TJ, Norfolk, England
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 25期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Peptides; Dipeptide; Urea; Isotopic labelling; GLUTAMATE CARBOXYPEPTIDASE-II; CARBON-DIOXIDE; INHIBITORS; ISOCYANATES; DESIGN; CATALYSIS; PROTEASE; AMINES; ANALOG;
D O I：
10.1002/ejoc.201500589
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe a flexible and high yielding synthesis of 1,3-disubstituted ureas that allows for the construction of both symmetrical and unsymmetrical dipeptide ureas, including easy access to C-13-labelled ureas, from amino acids and carbon dioxide at atmospheric pressure.
引用
收藏
页码：5603 / 5609
页数：7
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