Case only design to measure gene-gene interaction

被引：111

作者：

Yang, QH

Khoury, MJ

Sun, FZ

Flanders, WD

机构：

[1] Ctr Dis Control & Prevent, NCEH, Div Birth Defects & Dev Disabil, Atlanta, GA 30341 USA

[2] Ctr Dis Control & Prevent, Off Genet & dis Prevent, Atlanta, GA 30341 USA

[3] Emory Univ, Sch Med, Dept Genet, Atlanta, GA USA

[4] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA

来源：

EPIDEMIOLOGY | 1999年 / 10卷 / 02期

关键词：

case only design; epidemiologic methods; gene-gene interaction; genes; study design;

D O I：

10.1097/00001648-199903000-00014

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the frequencies of genes are independent in the population. Just as the case only design requires fewer cases than the case-control design to measure gene environment interaction, it also requires fewer cases to measure gene-gene interactions.

引用

页码：167 / 170

页数：4

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