Case only design to measure gene-gene interaction

被引：111
|
作者：
Yang, QH
Khoury, MJ
Sun, FZ
Flanders, WD
机构：
[1] Ctr Dis Control & Prevent, NCEH, Div Birth Defects & Dev Disabil, Atlanta, GA 30341 USA
[2] Ctr Dis Control & Prevent, Off Genet & dis Prevent, Atlanta, GA 30341 USA
[3] Emory Univ, Sch Med, Dept Genet, Atlanta, GA USA
[4] Emory Univ, Rollins Sch Publ Hlth, Dept Epidemiol, Atlanta, GA USA
来源：
EPIDEMIOLOGY | 1999年 / 10卷 / 02期
关键词：
case only design; epidemiologic methods; gene-gene interaction; genes; study design;
D O I：
10.1097/00001648-199903000-00014
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The case-only design is an efficient and valid approach to screening for gene-environment interaction under the assumption of the independence between exposure and genotype in the population. In this paper, we show that the case-only design is also a valid and efficient approach to measuring gene-gene interaction under the assumption that the frequencies of genes are independent in the population. Just as the case only design requires fewer cases than the case-control design to measure gene environment interaction, it also requires fewer cases to measure gene-gene interactions.
引用
收藏
页码：167 / 170
页数：4
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