The biological functions of T helper 17 cell effector cytokines in inflammation

被引：1517
|
作者：
Ouyang, Wenjun [1 ]
Kolls, Jay K. [2 ]
Zheng, Yan [3 ]
机构：
[1] Genentech Inc, Dept Immunol, San Francisco, CA 94080 USA
[2] Univ Pittsburgh, Childrens Hosp Pittsburgh, Dept Pediat, Div Pulm Med Allergy & Immunol, Pittsburgh, PA 15213 USA
[3] Pfizer Global Res & Dev, St Louis Labs, Inflammat Pathways Grp, Chesterfield, MO 63017 USA
来源：
IMMUNITY | 2008年 / 28卷 / 04期
关键词：
D O I：
10.1016/j.immuni.2008.03.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T helper 17 (Th17) cells belong to a recently identified T helper subset, in addition to the traditional Th1 and Th2 subsets. These cells are characterized as preferential producers of interleukin-17A (IL-17A), IL-17F, IL-21, and IL-22. Th17 cells and their effector cytokines mediate host defensive mechanisms to various infections, especially extracellular bacteria infections, and are involved in the pathogenesis of many autoimmune diseases. The receptors for IL-17 and IL-22 are broadly expressed on various epithelial tissues. The effector cytokines of Th17 cells, therefore, mediate the crucial crosstalk between immune system and tissues, and play indispensable roles in tissue immunity.
引用
收藏
页码：454 / 467
页数：14
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