The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells

被引：66

作者：

Grimm, Daniela ^{[1
,2
,3
]}

Wehland, Markus ^{[2
]}

Corydon, Thomas J. ^{[3
,4
]}

Richter, Peter ^{[5
]}

Prasad, Binod ^{[5
]}

Bauer, Johann ^{[6
]}

Egli, Marcel ^{[7
]}

Kopp, Sascha ^{[2
]}

Lebert, Michael ^{[5
,8
]}

Krueger, Marcus ^{[2
]}

机构：

[1] Otto von Guericke Univ, Dept Micrograv & Translat Regenerat Med, Magdeburg, Germany

[2] Otto von Guericke Univ, Clin Plast Aesthet & Hand Surg, Magdeburg, Germany

[3] Aarhus Univ, Dept Biomed, Aarhus, Denmark

[4] Aarhus Univ Hosp, Dept Ophthalmol, Aarhus, Denmark

[5] Friedrich Alexander Univ Erlangen Nuremberg, Dept Biol, Erlangen, Germany

[6] Max Planck Inst Biochem, Planegg Martinsried, Germany

[7] Lucerne Univ Appl Sci & Arts, Inst Med Engn, Space Biol Grp, Hergiswil, Switzerland

[8] Space Biol Unltd SAS, Bordeaux, France

来源：

STEM CELLS TRANSLATIONAL MEDICINE | 2020年 / 9卷 / 08期

关键词：

cancer stem cells; microgravity; multicellular spheroids; organoids; random positioning machine; rotating wall vessel; spaceflight; stem cells; tissue engineering; SIMULATED MICROGRAVITY; GENE-EXPRESSION; CHONDROGENIC DIFFERENTIATION; SPHEROID FORMATION; PROGENITOR CELLS; CULTURE-SYSTEM; BONE; PROLIFERATION; PROMOTES; ROTARY;

D O I：

10.1002/sctm.20-0084

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (mu g) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) mu g is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-mu g as well as the impact of mu g on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to mu g conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.

引用

页码：882 / 894

页数：13