Carbon disulfide promoted reactions of 2-chloro-4,5-dihydro-imidazole with some N-nucleophiles

被引：12

作者：

Saczewski, F ^{[1
]}

Saczewski, J

Gdaniec, M

机构：

[1] Med Univ Gdansk, Dept Chem Technol Drugs, PL-80416 Gdansk, Poland

[2] Adam Mickiewicz Univ Poznan, Fac Chem, PL-60780 Poznan, Poland

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2001年 / 49卷 / 09期

关键词：

2-chloro-4,5-dihydroimidazole; carbon disulfide; nucleophilic substitution; N-nucleophiles; 2-(4,5-dihydroimidazol-2-yl)-1H-indazole; X-ray analysis;

D O I：

10.1248/cpb.49.1203

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The reactions of 2-chloro-4,5-dihydroimidazole I with o-substituted anilines and azoles promoted by carbon disulfide have been carried out. Ab initio MO calculations were used to elucidate the mechanism of the reaction of 1 with N-nucleophilic reagents. A facile synthesis of 2-(4,5-dihydroimidazol-2-yl)-1H-indazole 3e bearing structural resemblances to 2-BFI, a potent and selective agonist of imidazoline I-2 receptors, is also described. Structure of 3e was confirmed by NMR spectroscopy and X-ray analysis.

引用

页码：1203 / 1206

页数：4

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