Breast cancer risk in mothers of twins

被引：14

作者：

Murphy, MFG

Broeders, MJM

Carpenter, LM

Gunnarskog, J

Leon, DA

机构：

[1] CATHOLIC UNIV NIJMEGEN,FAC MED SCI,DEPT MED INFORMAT & EPIDEMIOL,NL-6500 HB NIJMEGEN,NETHERLANDS

[2] UNIV OXFORD,RADCLIFFE INFIRM,DEPT PUBL HLTH & PRIMARY CARE,OXFORD OX2 6HE,ENGLAND

[3] NATL BOARD HLTH & WELF,CTR EPIDEMIOL,SOCIALSTYRELSEN,S-10630 STOCKHOLM,SWEDEN

[4] UNIV LONDON LONDON SCH HYG & TROP MED,DEPT EPIDEMIOL & POPULAT SCI,LONDON WC1E 7HT,ENGLAND

来源：

BRITISH JOURNAL OF CANCER | 1997年 / 75卷 / 07期

关键词：

breast cancer; parity; twinning;

D O I：

10.1038/bjc.1997.181

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The risk of breast cancer associated with delivering a twin birth was examined in a population-based nested case - control study of nearly 4800 Swedish women with breast cancer and 47000 age-matched control subjects. AII were aged less than 50 years and parous. After adjustment for age at first birth and parity, a 29% reduction in breast cancer risk was observed in mothers of twins relative to those who were not (odds ratio = 0.71, 95% confidence interval 0.55-0.91). These results provide evidence that women who bear twins are at reduced risk of breast cancer, one explanation for which may be their unusual levels of hormonal exposure.

引用

页码：1066 / 1068

页数：3

共 14 条

[1]

ALBREKTSEN G, 1995, INT J CANCER, V60, P341, DOI 10.1002/ijc.2910600311

[2]

[Anonymous], 1993, EPICURE USERS GUIDE

[3]

BERNSTEIN L, 1993, BREAST CANC, P48

[4] MULTIPLE BIRTHS AND RISK OF BREAST-CANCER [J].