Three-component synthesis of 1,4-diazepin-5-ones and the construction of γ-turn-like peptidomimetic libraries

被引：17

作者：

Fenster, Erik ^{[1
,2
]}

Rayabarapu, Dinesh K. ^{[1
,3
]}

Zhang, Mianji ^{[1
,3
]}

Mukherjee, Shubhasish ^{[1
,3
]}

Hill, David ^{[1
]}

Neuenswander, Ben ^{[1
]}

Schoenen, Frank ^{[1
]}

Hanson, Paul R. ^{[1
,3
]}

Aube, Jeffrey ^{[1
,2
]}

机构：

[1] Univ Kansas, KU Chem Methodol & Lib Dev Ctr, Lawrence, KS 66047 USA

[2] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA

[3] Univ Kansas, Dept Chem, Lawrence, KS 66045 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2008年 / 10卷 / 02期

关键词：

D O I：

10.1021/cc700174c

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The parallel synthesis of gamma-turn-inspired peptidomimetic libraries has been demonstrated through two approaches toward the preparation of 1,4-diazepin-5-ones. In the first approach, 1,4-diazepin-5-ones scaffolds were prepared on gram scale and subsequently diversified to produce libraries. In a second approach, libraries of 1,4-diazepin-5-ones were produced directly through a three-component strategy that maximizes the diversity obtained in a single step.

引用

页码：230 / 234

页数：5

共 48 条

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