Methadone tapering plus amantadine to detoxify heroin-dependent inpatients with or without an active cocaine use disorder: two randomised controlled trials

被引：16

作者：

de los Cobos, JP ^{[1
]}

Duro, P ^{[1
]}

Trujols, J ^{[1
]}

Tejero, A ^{[1
]}

Batlle, F ^{[1
]}

Ribalta, E ^{[1
]}

Casas, M ^{[1
]}

机构：

[1] Univ Barcelona, Sch Med, Hosp Santa Cruz & San Pablo, Dept Psychiat, Barcelona 08025, Spain

来源：

DRUG AND ALCOHOL DEPENDENCE | 2001年 / 63卷 / 02期

关键词：

amantadine; cocaine use disorder; detoxification; heroin dependence; methadone; opioid withdrawal;

D O I：

10.1016/S0376-8716(00)00206-4

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

The efficacy of methadone tapering plus amantadine to detoxify heroin-dependent patients with or without an active cocaine use disorder was studied in a closed unit with two successive double-blind, placebo-controlled, Ip-day trials. In the first trial, 40 heroin-dependent inpatients with an active cocaine use disorder were treated using methadone tapering, as well as amantadine (200-300 mg per day) or placebo. In the second trial, 40 heroin-dependent inpatients without an active cocaine use disorder received the same treatment. In both the trials, amantadine did not have a statistically significant effect on treatment completion, nor did it contribute, in completers, to a more rapid reduction in craving and opiate withdrawal. In the first trial, women were six times more likely than men to be non-completers, and on the last day of treatment, the first trial's completers and non-completers presented a comparable clinical state. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：187 / 195

页数：9