Mast cell/MDSC a liaison immunosuppressive for tumor microenvironment

被引：27
作者：
Danelli, Luca [1 ,2 ]
Frossi, Barbara [1 ]
Pucillo, Carlo E. [1 ]
机构：
[1] Univ Udine, Dept Med & Biol Sci, I-33100 Udine, Italy
[2] Univ Paris Diderot, Sorbonne Paris Cite, Lab Excellence INFLAMEX, INSERM,UMRS 1149,CNRS ERL 8252, Paris, France
来源：
ONCOIMMUNOLOGY | 2015年 / 4卷 / 04期
关键词：
CD40:CD40L; colon carcinoma; immunosuppression; mast cells; myeloid derived suppressor cells; SUPPRESSOR-CELLS;
D O I：
10.1080/2162402X.2014.1001232
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The instauration of an immunosuppressive microenvironment is a key event in cancer development and progression. Here, we discuss increasing evidences of the crosstalk between myeloid- derived suppressor cells (MDSCs) and mast cells (MCs) as a new fuel for the cancer immunosuppressive machinery.
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