Pain and stress: functional evidence that supra-spinal mechanisms involved in pain-induced analgesia mediate stress-induced analgesia

被引:6
作者
Tobaldini, Glaucia [1 ,2 ]
Andersen, Erik O. L. [1 ]
Polato, Jhuliana J. [1 ]
Guilhen, Vinicius A. [1 ]
Gaspar, Jessica C. [1 ]
Lazzarim, Mayla K. [1 ]
Sardi, Natalia F. [1 ]
Fischer, Luana [1 ]
机构
[1] Univ Fed Parana, Dept Physiol, Div Biol Sci, Av Francisco H Santos, BR-81531980 Curitiba, Parana, Brazil
[2] Posit Univ, Curitiba, Parana, Brazil
来源
BEHAVIOURAL PHARMACOLOGY | 2020年 / 31卷 / 2-3期
关键词
ascending nociceptive control; aversion; capsaicin; descending system; nucleus accumbens; pain-induced analgesia; periaqueductal gray; rostral ventromedial medulla; stress-induced analgesia; ASCENDING NOCICEPTIVE CONTROL; NUCLEUS-ACCUMBENS CIRCUITRY; PARAVENTRICULAR NUCLEUS; INDUCED ANTINOCICEPTION; RESTRAINT STRESS; RECEPTORS; FORMALIN; HYPERALGESIA; FOS;
D O I
10.1097/FBP.0000000000000529
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Analgesia induced by stressful and painful stimuli is an adaptive response during life-threatening situations. There is no evidence linking the mechanisms underlying them, while the former depends on the activation of stress-related brain pathways, the second depends on opioidergic mechanisms in the nucleus accumbens and on nicotinic cholinergic mechanisms in the rostral ventromedial medulla. In this study, we hypothesized that stress-induced analgesia is also dependent on opioidergic mechanisms in the nucleus accumbens and on nicotinic cholinergic mechanisms in the rostral ventromedial medulla. We used immobilization, a classical procedure to induce acute stress, and evaluated its ability to decrease the nociceptive responses induced either by carrageenan or by formalin in rats. Immobilization stress significantly decreased either carrageenan-induced hyperalgesia or formalin-induced tonic nociception in a time-dependent manner. This stress-induced analgesia is similar to pain-induced analgesia, as revealed by contrasting the antinociceptive effect induced by immobilization and by a forepaw injection of capsaicin. The administration of a mu-opioid receptor antagonist (CTOP, 0.5 mu g) into the nucleus accumbens, as well as that of a nicotinic cholinergic receptor antagonist (mecamylamine, 0.6 mu g) into the rostral ventromedial medulla, blocked immobilization stress-induced analgesia in both pain models. These results demonstrate that supraspinal mechanisms which are known to mediate pain-induced analgesia also mediate stress-induced analgesia. Therefore both forms of analgesia have overlapping mechanisms, probably recruited in response to the perception of danger.
引用
收藏
页码:159 / 167
页数:9
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