Pyruvate kinase M2 at a glance

被引：165

作者：

Yang, Weiwei ^{[1
,2
]}

Lu, Zhimin ^{[3
,4
,5
,6
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai 200031, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl, Shanghai 200031, Peoples R China

[3] Univ Texas MD Anderson Canc Ctr, Brain Tumor Ctr, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Neurooncol, Houston, TX 77030 USA

[5] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[6] Univ Texas Houston, Canc Biol Program, Grad Sch Biomed Sci Houston, Houston, TX 77030 USA

来源：

JOURNAL OF CELL SCIENCE | 2015年 / 128卷 / 09期

基金：

美国国家科学基金会;

关键词：

PKM2; Pyruvate kinase M2; Metabolism reprogramming; Protein kinase; Gene transcription; TUMOR-GROWTH; PROTEIN-KINASE; NUCLEAR TRANSLOCATION; GENE-TRANSCRIPTION; CELL-PROLIFERATION; CANCER METABOLISM; PKM2; EXPRESSION; BINDING PROTEIN; ISOFORM M2; PROMOTES;

D O I：

10.1242/jcs.166629

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment.

引用

页码：1655 / 1660

页数：6

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