Steroidal alkaloid saponins and steroidal saponins from Solanum surattense

被引：64

作者：

Lu, Yuanyuan ^{[1
]}

Luo, Jianguang ^{[1
]}

Kong, Lingyi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

PHYTOCHEMISTRY | 2011年 / 72卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Solanaceae; Solanum surattense; Steroidal alkaloid saponin; Avenacoside-type saponin; Steroidal saponin; Cytotoxicity; GLYCOSIDES; TORVUM; PLANTS; SAPOGENINS; SOLASODINE; FRUITS; C-22;

D O I：

10.1016/j.phytochem.2011.01.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A rare 16 beta-H steroidal alkaloid saponin (1), an avenacoside-type saponin (2), two steroidal saponins (4, 5), one revised-structure steroidal saponin (3) and six known compounds (6-11) were isolated from aerial parts of Solanum surattense Burm. f. Their structures were established on the basis of physical data, as well as by using spectroscopic (HRESIMS, 1D and 2D NMR), and chemical analysis methods. Compounds 1 and 11 showed cytotoxicity against A549 cell line with IC(50) values of 20.3 and 15.7 mu M, respectively. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：668 / 673

页数：6

共 18 条

[1] Antiviral isoflavonoid sulfate and steroidal glycosides from the fruits of Solanum torvum [J].

Arthan, D ;

Svasti, J ;

Kittakoop, P ;

Pittayakhachonwut, D ;

Tanticharoen, M ;

Thebtaranonth, Y .

PHYTOCHEMISTRY, 2002, 59 (04) :459-463

[2] Hydrogen atom transfer methodology for the synthesis of C-22, C-23, and C-25 stereoisomers of cephalostatin north 1 side chain from spirostan sapogenins [J].

Betancor, C ;

Freire, R ;

Pérez-Martín, I ;

Prangé, T ;

Suárez, E .

TETRAHEDRON, 2005, 61 (11) :2803-2814

[3] Antiinflammatory activity of Solanum trilobatum [J].

Emmanuel, S. ;

Ignacimuthu, S. ;

Perumalsamy, R. ;

Amalraj, T. .

FITOTERAPIA, 2006, 77 (7-8) :611-612

[4]

Gawande A, 1990, INDIAN DRUGS, V28, P149

[5]

HARA S, 1987, CHEM PHARM BULL, V35, P501

[6] Three unusual 22-β-O-23-hydroxy-(5α)-spirostanol glycosides from the fruits of Solanum torvum [J].

Iida, Y ;

Yanai, Y ;

Ono, M ;

Ikeda, T ;

Nohara, T .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2005, 53 (09) :1122-1125

[7] Four new steroidal glycosides from Solanum torvum and their cytotoxic activities [J].

Lu, Yuanyuan ;

Luo, Jianguang ;

Huang, Xuefeng ;

Kong, Lingyi .

STEROIDS, 2009, 74 (01) :95-101

[8] STIMULATION OF SOLASODINE PRODUCTION BY COMBINING FUNGAL ELICITORS AND IMMOBILIZED CELL-SUSPENSION CULTURES OF - SOLANUM-SURATTENSE BURM [J].

MALPATHAK, NP ;

DAVID, SB .

BIOTECHNOLOGY LETTERS, 1992, 14 (10) :965-968

[9]

MALPATHAK NP, 1994, INDIAN DRUGS, V31, P73

[10] Distinction of absolute configuration at C-22 of C-23-hydroxyspirostane and C-23-hyrodoxyspirosolane glycosides [J].

Matsushita, Sayaka ;

Yanai, Yoshihiro ;

Fusyuku, Asami ;

Ikeda, Tsuyoshi ;

Ono, Masateru ;

Nohara, Toshihiro .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (07) :1079-1081

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