Exogenous and intracellularly generated sphingosine 1-phosphate can regulate cellular processes by divergent pathways

被引：2
作者：
Spiegel, S
Milstien, S
机构：
[1] Virginia Commonwealth Univ, Dept Biochem, Richmond, VA 23298 USA
[2] NIH, Natl Inst Mental Hlth, Lab Cellular & Mol Regulat, Bethesda, MD 20892 USA
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2003年 / 31卷
关键词：
cell growth and survival; G-protein-coupled receptor (GPCR); sphingosine kinase; sphingosine 1-phosphate (S1P); sphingosine 1-phosphate receptor; tetrahydrobiopterin;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
S1P (sphingosine 1-phosphate) is the ligand for a family of specific G-protein-coupled receptors that regulate a wide variety of important cellular functions, including vascular maturation, angiogenesis, cell growth, survival, cytoskeletal rearrangements and cell motility. However, S1P also may have intracellular functions. in this review, we discuss two examples that clearly indicate that intracellularly generated and exogenous S1P can regulate biological processes by divergent pathways.
引用
收藏
页码：1216 / 1219
页数：4
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