Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study

被引：0
|
作者：
Kuru, Oguzhan [1 ]
Akgor, Utku [2 ]
Cakir, Ilker [1 ]
Tosun, Ozgur [3 ]
Yuksel, Ilkbal Temel [4 ]
Ulker, Volkan [4 ]
Meydanli, Mutlu [5 ]
Sanci, Muzaffer [1 ]
Gokcu, Mehmet [1 ]
Topuz, Samet [3 ]
Yildiz, Ferah [6 ]
Sakinci, Mehmet [7 ]
Salman, Mehmet Coskun [2 ]
Ozgul, Nejat [2 ]
Yuce, Kunter [2 ]
Ayhan, Ali [8 ]
机构：
[1] Izmir Tepecik Training & Res Hosp, Dept Gynecol Oncol, Izmir, Turkey
[2] Hacettepe Univ, Fac Med, Dept Gynecol Oncol, TR-06100 Ankara, Turkey
[3] Istanbul Univ, Fac Med, Dept Gynecol Oncol, Istanbul, Turkey
[4] Kanuni Sultan Suleyman Training & Res Hosp, Dept Gynecol Oncol, Istanbul, Turkey
[5] Zekai Tahir Burak Womens Hlth Training & Res Hosp, Dept Gynecol Oncol, Ankara, Turkey
[6] Hacettepe Univ, Fac Med, Dept Radiat Oncol, Ankara, Turkey
[7] Akdeniz Univ, Dept Obstet & Gynecol, Fac Med, Antalya, Turkey
[8] Baskent Univ, Fac Med, Dept Gynecol Oncol, Ankara, Turkey
来源：
UHOD-ULUSLARARASI HEMATOLOJI-ONKOLOJI DERGISI | 2020年 / 30卷 / 01期
关键词：
Metformin; Prognosis; Recurrence; Survival; Vulvar cancer; MARGIN DISTANCE; CANCER; RECURRENCE; PATTERNS; METFORMIN; SURVIVAL; DRUG;
D O I：
10.4999/uhod.204053
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The study aim to determine the clinicopathological factors for disease-free survival (DFS) and overall survival (OS) in women with vulvar cancer and to analyze the the possible effect of metformin on survival of the patients. From 2011 to 2017, medical records of 142 patients who underwent primary radical surgery for VC at 6 referral centers in Turkey were collected, retrospectively. The median age of the cohort was 67.0 years. 124 patients underwent radical surgery and inguinofemoral lymphadenectomy. The overall recurrence rate was 33.8% within a median follow-up time of 22 months. Five-year DFS and OS rates were 55.8% and 62.6%, respectively. Multivariate analysis showed surgical margin (HR:6.4, p= 0.017 for DFS; HR: 13.6, p=0.009 for OS) and lymph node metastasis (HR: 4.1, p= 0.014 for DFS; HR: 6.3, p= 0.020 for OS) were the independent prognostic factors. There was no statistically difference in DFS and OS for patients who had used metformin.
引用
收藏
页码：54 / 62
页数：9
相关论文
共 50 条
  • [41] Prognostic outcomes of oral squamous cell carcinoma derived from proliferative verrucous leukoplakia: A systematic review
    Faustino, Isabel Schausltz Pereira
    de Pauli Paglioni, Mariana
    de Almeida Mariz, Bruno Augusto Linhares
    Normando, Ana Gabriela Costa
    Perez-de-Oliveira, Maria Eduarda
    Georgaki, Maria
    Nikitakis, Nikolaos G.
    Vargas, Pablo Agustin
    Santos-Silva, Alan Roger
    Lopes, Marcio Ajudarte
    ORAL DISEASES, 2023, 29 (04) : 1416 - 1431
  • [42] The prognostic value of preoperative prognostic nutritional index in patients with hypopharyngeal squamous cell carcinoma: a retrospective study
    Ye, Lu-Lu
    Oei, Ronald Wihal
    Kong, Fang-Fang
    Du, Cheng-Run
    Zhai, Rui-Ping
    Ji, Qing-Hai
    Hu, Chao-Su
    Ying, Hong-Mei
    JOURNAL OF TRANSLATIONAL MEDICINE, 2018, 16
  • [43] Management of Advanced Squamous Cell Carcinoma of the Vulva
    Rogers, Linda J.
    CANCERS, 2022, 14 (01)
  • [44] Assessment of Prognostic Nutritional Index as a Preoperative Prognostic Indicator in Oral Squamous Cell Carcinoma: A Retrospective Study at a Tertiary Centre in India
    Achar, Amruta T.
    Prasad, Kavitha
    Rajanikanth, B. R.
    Kapali, Aravind S.
    JOURNAL OF MAXILLOFACIAL & ORAL SURGERY, 2024,
  • [45] Prognostic factors and survival for malignant conjunctival melanoma and squamous cell carcinoma over four decades
    Abt, Icholas B.
    Zhao, Jiawei
    Huang, Yuru
    Eghrari, Allen O.
    AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2019, 40 (04) : 577 - 582
  • [46] Prognostic Factors for Patients With Esophageal Squamous Cell Carcinoma After Neoadjuvant Chemotherapy Followed by Surgery
    Kitasaki, Nao
    Hamai, Yoichi
    Emi, Manabu
    Kurokawa, Tomoaki
    Yoshikawa, Toru
    Hirohata, Ryosuke
    Ohsawa, Manato
    Okada, Morithito
    IN VIVO, 2022, 36 (06): : 2852 - 2860
  • [47] Prognostic value of a mandibular canal staging system for primary lesions in patients with lower gingival squamous cell carcinoma: a multicenter, retrospective study
    Yamakawa, Nobuhiro
    Okura, Masaya
    Hasegawa, Takumi
    Otsuru, Mitsunobu
    Sakai, Hironori
    Hirai, Eiji
    Rin, Shin
    Yamada, Shin-ichi
    Yanamoto, Souichi
    Yokota, Yusuke
    Umeda, Masahiro
    Kurita, Hiroshi
    Ueda, Michihiro
    Akashi, Masaya
    Kirita, Tadaaki
    INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 2024, 29 (08) : 1122 - 1132
  • [48] Immune stromal features in cervical squamous cell carcinoma are prognostic factors for distant metastasis: A retrospective study
    Cao, Lanqing
    Sun, Ping-Li
    He, Yangyang
    Yao, Min
    Gao, Hongwen
    PATHOLOGY RESEARCH AND PRACTICE, 2020, 216 (03)
  • [49] Prognostic factors of oral squamous cell carcinoma: the importance of recurrence and pTNM stage
    Min Jae Kim
    Kang-Min Ahn
    Maxillofacial Plastic and Reconstructive Surgery, 46
  • [50] Surgical management of invasive carcinoma of the vulva. A retrospective analysis and review
    Konidaris, S.
    Bakas, P.
    Gregoriou, O.
    Kalampokas, Th.
    Kondi-Pafiti, A.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2011, 32 (05) : 505 - 508
12345