Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME)

被引：198

作者：

Heringa, MB ^{[1
]}

Hermens, JLM ^{[1
]}

机构：

[1] Univ Utrecht, IRAS, Div Toxicol, NL-3508 TD Utrecht, Netherlands

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2003年 / 22卷 / 09期

关键词：

calibration; free concentration; kinetics; matrix; microextraction; negligible depletion; solid phase microextraction;

D O I：

10.1016/S0165-9936(03)01006-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Measurement of free concentration is necessary to determine the effective or bioavailable quantity of a chemical, and is also a way of determining the binding affinity or partition coefficient of a compound. This review gives a brief overview of the methods available to measure free concentrations and will focus on negligible depletion-solid phase microextraction (nd-SPME). Theoretical as well as experimental details of the method are discussed, including potential confounding factors, such as fouling, diffusion layer effects, and calibration. (C) 2003 Published by Elsevier B.V.

引用

页码：575 / 587

页数：13

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