共 22 条
Chemokine C-C Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study
被引:9
作者:
Waskiel-Burnat, Anna
[1
]
Niemczyk, Anna
[1
]
Blicharz, Leszek
[1
]
Chmielinska, Paulina
[1
]
Zaremba, Michal
[1
]
Gasecka, Aleksandra
[2
]
Filipiak, Krzysztof J.
[3
]
Olszewska, Malgorzata
[1
]
Rudnicka, Lidia
[1
]
机构:
[1] Med Univ Warsaw, Dept Dermatol, PL-02008 Warsaw, Poland
[2] Med Univ Warsaw, Chair & Dept Cardiol 1, PL-02097 Warsaw, Poland
[3] Maria Sklodowska Curie Med Acad, Inst Clin Sci, Pl Zelaznej Bramy 10, PL-00136 Warsaw, Poland
关键词:
cardiovascular disease;
coronary artery disease;
heart disease;
hair loss;
stroke;
myocardial infarction;
peripheral arterial disease;
CARDIOVASCULAR RISK;
D O I:
10.3390/jcm10225418
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Alopecia areata is an autoimmune, inflammatory form of non-scarring hair loss that may affect any hair-bearing area. Recently, an increased risk of cardiovascular disorders has been described in patients with alopecia areata. The aim of the study was to evaluate the serum concentrations of proinflammatory proteins associated with atherosclerosis (chemokine C-C motif ligand 4; CCL4, chemokine C-C motif ligand 7, CCL7; and sortilin, SORT1), and cardiovascular risk (myeloperoxidase, MPO; interleukin 1 receptor-like 1, IL1RL1; and growth differentiation factor 15, GDF15) in patients with alopecia areata without symptoms or prior cardiovascular disease in comparison with healthy controls. Sixty otherwise healthy patients with alopecia areata and twenty control subjects matched for age, gender, and body mass index (BMI) were enrolled in the study. No significant differences in the serum levels of MPO, IL1RL1, CCL4, CCL7, SORT1, and GDF15 were detected between patients with alopecia areata and healthy controls. A positive correlation was found between the serum concentration of CCL7 and the severity of alopecia areata (r = 0.281, p = 0.03), while GDF15 correlated with age at the disease onset (r = 0.509, p < 0.0001). The results of the present study suggest that the severity of alopecia areata may be associated with an increased risk of atherosclerosis.
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页数:10
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