AlCl3-PROMOTED CYCLIZATION OF β-KETO DERIVATIVES WITH IN SITU GENERATED ENAMINES UNDER SOLVENT-FREE HIGH SPEED BALL MILLING: AN EFFICIENT ONE-POT ACCESS TO POLYSUBSTITUTED 1,4-DIHYDROPYRIDINES

被引：3

作者：

Zeng, Ji-Chao ^{[1
]}

Yu, Fei ^{[1
]}

Asiri, Abdullah M. ^{[2
]}

Marwani, Hadi M. ^{[2
]}

Zhang, Ze ^{[1
]}

机构：

[1] Anhui Polytech Univ, Sch Biol & Chem Engn, Wuhu 241000, Peoples R China

[2] King Abdulaziz Univ, Fac Sci, Chem Dept, Jeddah 21589, Saudi Arabia

来源：

HETEROCYCLES | 2017年 / 94卷 / 11期

关键词：

1,4-Dihydropyridine; High Speed Ball Milling (HSBM); Solvent-Free Reaction; Cyclization Reaction; Enamine; SUBSTITUTED 1,4-DIHYDROPYRIDINES; POLYHYDROQUINOLINE DERIVATIVES; 1,3-DICARBONYL COMPOUNDS; 3-COMPONENT CYCLIZATION; ORGANIC-SYNTHESIS; DIHYDROPYRIDINES; CHEMISTRY; ALDEHYDES; ACID; TETRAHYDROPYRIDINES;

D O I：

10.3987/COM-17-13801

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Under high speed ball milling (HSBM), a simple method for efficient synthesis of structurally diverse polysubstituted 1,4-dihydropyridines is developed via AlCl3-promoted Robinson-like cyclization of beta-keto derivatives with in situ generated enamines. This one-pot protocol exhibits the advantages of high chemoselectivity, short reaction time, good functional group tolerance, mild reaction condition and easy work-up.

引用

页码：2054 / 2064

页数：11

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