Rumphellclovane B, a Novel Clovane Analogue from the Gorgonian Coral Rumphella antipathies

被引：16

作者：

Chung, Hsu-Ming ^{[1
,2
]}

Hwang, Tsong-Long ^{[3
]}

Chen, Yung-Husan ^{[2
]}

Su, Jui-Hsin ^{[2
]}

Lu, Mei-Chin ^{[2
,4
]}

Chen, Jih-Jung ^{[5
]}

Li, Jan-Jung ^{[2
]}

Fang, Lee-Shing ^{[6
]}

Wang, Wei-Hsien ^{[1
,2
,7
]}

Sung, Ping-Jyun ^{[1
,2
,4
,7
,8
,9
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Museum Marine Biol & Aquarium, Pingtung 944, Taiwan

[3] Chang Gung Univ, Grad Inst Nat Prod, Tao Yuan 333, Taiwan

[4] Natl Dong Hwa Univ, Grad Inst Marine Biotechnol, Pingtung 944, Taiwan

[5] Tajen Univ, Dept Pharm, Pingtung 907, Taiwan

[6] Cheng Shiu Univ, Dept Sport Hlth & Leisure, Kaohsiung 833, Taiwan

[7] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

[8] Natl Dong Hwa Univ, Dept Life Sci, Hualien 974, Taiwan

[9] Natl Dong Hwa Univ, Inst Biotechnol, Hualien 974, Taiwan

来源：

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2011年 / 84卷 / 01期

关键词：

CARYOPHYLLANE;

D O I：

10.1246/bcsj.20100253

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel clovane-type sesquiterpenoid derivative, rumphellclovane B (1), which possesses an unprecedented delta-lactone moiety, and a new natural clovane, 9 alpha-hydroxyclovan-2-one (2), were isolated from the gorgonian coral Rumphella antipathies. The structures of clovanes 1 and 2 were elucidated by interpretations of spectral data. A plausible biosynthetic pathway between these two compounds was proposed. Compound 1 displayed inhibitory effects on superoxide anion generation by human neutrophils.

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收藏

页码：119 / 121

页数：3

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