Why QRS Duration Should Be Replaced by Better Measures of Electrical Activation to Improve Patient Selection for Cardiac Resynchronization Therapy

被引：28

作者：

Engels, Elien B. ^{[1
]}

Mafi-Rad, Masih ^{[2
]}

van Stipdonk, Antonius M. W. ^{[2
]}

Vernooy, Kevin ^{[2
]}

Prinzen, Frits W. ^{[1
]}

机构：

[1] Maastricht Univ, Cardiovasc Res Inst Maastricht, Dept Physiol, Maastricht, Netherlands

[2] Maastricht Univ, Dept Cardiol, Med Ctr, Maastricht, Netherlands

来源：

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH | 2016年 / 9卷 / 04期

关键词：

Electrocardiography; Vectorcardiography; Cardiac mapping; Cardiac resynchronization therapy; Left bundle-branch block; BUNDLE-BRANCH BLOCK; LEFT-VENTRICULAR ACTIVATION; HEART-FAILURE; TASK-FORCE; ENDOCARDIAL ACTIVATION; PREDICTS RESPONSE; EUROPEAN-SOCIETY; ESC GUIDELINES; 12-LEAD ECG; ASSOCIATION;

D O I：

10.1007/s12265-016-9693-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac resynchronization therapy (CRT) is a well-known treatment modality for patients with a reduced left ventricular ejection fraction accompanied by a ventricular conduction delay. However, a large proportion of patients does not benefit from this therapy. Better patient selection may importantly reduce the number of non-responders. Here, we review the strengths and weaknesses of the electrocardiogram (ECG) markers currently being used in guidelines for patient selection, e.g., QRS duration and morphology. We shed light on the current knowledge on the underlying electrical substrate and the mechanism of action of CRT. Finally, we discuss potentially better ECG-based biomarkers for CRT candidate selection, of which the vectorcardiogram may have high potential.

引用

页码：257 / 265

页数：9

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