New Psoriasis Susceptibility Genes: Momentum for Skin-Barrier Disruption

被引：19

作者：

Coto, Eliecer ^{[1
,2
]}

Santos-Juanes, Jorge ^{[1
,2
]}

Coto-Segura, Pablo ^{[1
]}

Alvarez, Victoria ^{[1
]}

机构：

[1] Hosp Univ Cent Asturias, Serv Salud Principado Asturias, Oviedo, Spain

[2] Univ Oviedo, Dept Med, Oviedo, Spain

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2011年 / 131卷 / 05期

关键词：

CALCIUM;

D O I：

10.1038/jid.2011.14

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The epidermal differentiation complex gene cluster is on chromosome region 1q21.3, where the PSORS4 locus was mapped. A common deletion of two LCE genes (LCE3C_LCE3B-del) was associated with psoriasis. Individuals homozygous for the deletion have an impaired response of the skin barrier to exogenous agents, facilitating the systemic skin inflammation characteristic of psoriasis.

引用

页码：1003 / 1005

页数：3

共 13 条

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