Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro

被引：30

作者：

Borgonovo, Gigliola ^{[1
]}

De Petrocellis, Luciano ^{[2
]}

Moriello, Aniello Schiano ^{[2
,3
]}

Bertoli, Simona ^{[1
]}

Leone, Alessandro ^{[1
]}

Battezzati, Alberto ^{[1
]}

Mazzini, Stefania ^{[1
]}

Bassoli, Angela ^{[1
]}

机构：

[1] Univ Milan, Dept Food Environm & Nutr DeFENS, Via Celoria 2, I-20133 Milan, Italy

[2] CNR, Endocannabinoid Res Grp, Inst Biomol Chem, I-87078 Naples, Italy

[3] Epitech Grp SpA, I-35030 Padua, Italy

来源：

MOLECULES | 2020年 / 25卷 / 04期

关键词：

Moringa oleifera; moringin; TRPA1 ion channel; isothiocyanates; MUSTARD OIL; EXTRACT; LEAVES; DESENSITIZATION; GLUCOSINOLATE; HEALTH; TRPV1;

D O I：

10.3390/molecules25040976

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Moringa oleifera Lam. is a tropical plant widely used in traditional medicines and as a food supplement. It is characterized by the presence of glucosinolates and isothiocyanates; the stable isothiocyanate 4-[(alpha-L-rhamnosyloxy)benzyl]isothiocyanate (moringin) has been widely studied for its bioactivity as hypoglycemic, antimicrobial, anticancer and in particular for its involvement in nociception and neurogenic pain. Moringa extracts and pure moringin were submitted to in vitro assays with the somatosensory TRPA1 ion channel, proving that moringin is a potent and effective agonist of this receptor involved in nociceptive function and pain states. Moringin do not activate or activates very weakly the vanilloids somatosensory channels TRPV1,2,3 and 4, and the melastatin cooling receptor TRPM8. The comparison of moringin's activity with other known agonists of natural origin is also discussed.

引用

页数：12

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